A probable role of copper in the comorbidity in Wilson's and Creutzfeldt-Jakob's Diseases: A case report

Koutsouraki E., Michmizos D., Patsi O., Tzartos J., Spilioti M., Arnaoutoglou M., Tsolaki M.

dc.creator	Koutsouraki E., Michmizos D., Patsi O., Tzartos J., Spilioti M., Arnaoutoglou M., Tsolaki M.	en
dc.date.accessioned	2023-01-31T08:46:29Z
dc.date.available	2023-01-31T08:46:29Z
dc.date.issued	2020
dc.identifier	10.1186/s12985-020-01309-x
dc.identifier.issn	1743422X
dc.identifier.uri	http://hdl.handle.net/11615/75442
dc.description.abstract	Background: To the best of our knowledgedd, there is currently no case in the literature reporting the comorbidity of Wilson's and Creutzfeldt-Jakob disease (CJD), linked through copper. Case presentation: A 44-year-old male with a history of inherited Wilson's disease (hepatolenticular degeneration), which manifested as mild liver injury and psychiatric symptoms, was admitted to our department due to speech and cognitive disturbances. Upon his admission, he had motor aphasia as well as psychomotor retardation with an otherwise normal neurological examination. Laboratory tests, including liver enzymes, copper and serum ammonia were all within normal range. The brain MRI showed increased T2 signal in the caudate nuclei, attributed to copper deposition in the context of Wilson's disease. In the electroencephalogram, periodic sharp discharges were eminent, initially unilateral and then generalized. The positive 14-3-3 protein in the cerebrospinal fluid (CSF) and the new brain MRI, that demonstrated elevated DWI signal not only in the basal ganglia but also in parts of the cerebral cortex (cortical ribbon sign), all supportive of a possible CJD diagnosis. The detection of PrPSc in the patient's CSF, using the RT-QuIC method, which has a 99.4-100% specificity for CJD, made the diagnosis of CJD highly probable. Conclusion: This is the first report of Wilson's and Creutzfeldt-Jakob diseases co-morbidity in the literature, which could evoke a possible role of copper in the pathogenesis of CJD. © 2020 The Author(s).	en
dc.language.iso	en	en
dc.source	Virology Journal	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081962516&doi=10.1186%2fs12985-020-01309-x&partnerID=40&md5=1d18605c24f0c2af7d54611546e18fff
dc.subject	benzodiazepine derivative	en
dc.subject	ceruloplasmin	en
dc.subject	copper	en
dc.subject	levetiracetam	en
dc.subject	methylprednisolone	en
dc.subject	prion protein	en
dc.subject	stratifin	en
dc.subject	copper	en
dc.subject	adult	en
dc.subject	aphasia	en
dc.subject	Article	en
dc.subject	ataxic aphasia	en
dc.subject	bipolar disorder	en
dc.subject	case report	en
dc.subject	caudate nucleus	en
dc.subject	ceruloplasmin blood level	en
dc.subject	clinical article	en
dc.subject	clinical feature	en
dc.subject	cognitive defect	en
dc.subject	comorbidity assessment	en
dc.subject	consciousness level	en
dc.subject	Creutzfeldt Jakob disease	en
dc.subject	death	en
dc.subject	disease severity	en
dc.subject	drug megadose	en
dc.subject	electroencephalogram	en
dc.subject	emergency health service	en
dc.subject	epileptic state	en
dc.subject	familial disease	en
dc.subject	family history	en
dc.subject	general condition deterioration	en
dc.subject	Glasgow coma scale	en
dc.subject	hospital admission	en
dc.subject	human	en
dc.subject	liver injury	en
dc.subject	male	en
dc.subject	mental disease	en
dc.subject	metabolic fingerprinting	en
dc.subject	mutismus	en
dc.subject	nuclear magnetic resonance imaging	en
dc.subject	pathogenesis	en
dc.subject	polymerase chain reaction	en
dc.subject	protein analysis	en
dc.subject	protein cerebrospinal fluid level	en
dc.subject	psychomotor retardation	en
dc.subject	repeat procedure	en
dc.subject	spatiotemporal analysis	en
dc.subject	tendon reflex	en
dc.subject	treatment response	en
dc.subject	Wilson disease	en
dc.subject	brain	en
dc.subject	cerebrospinal fluid	en
dc.subject	comorbidity	en
dc.subject	complication	en
dc.subject	Creutzfeldt Jakob disease	en
dc.subject	diagnostic imaging	en
dc.subject	electroencephalography	en
dc.subject	pathology	en
dc.subject	pathophysiology	en
dc.subject	Wilson disease	en
dc.subject	Adult	en
dc.subject	Brain	en
dc.subject	Comorbidity	en
dc.subject	Copper	en
dc.subject	Creutzfeldt-Jakob Syndrome	en
dc.subject	Electroencephalography	en
dc.subject	Hepatolenticular Degeneration	en
dc.subject	Humans	en
dc.subject	Magnetic Resonance Imaging	en
dc.subject	Male	en
dc.subject	BioMed Central Ltd.	en
dc.title	A probable role of copper in the comorbidity in Wilson's and Creutzfeldt-Jakob's Diseases: A case report	en
dc.type	journalArticle	en

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Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19705]

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