Interstitial lung disease in anti-synthetase syndrome

Kourkouni E., Mitsogiannis G., Simopoulou T., Liaskos C., Katsiari C.G., Daniil Z., Gourgoulianis K., Bogdanos D.P., Sakkas L.I.

dc.creator	Kourkouni E., Mitsogiannis G., Simopoulou T., Liaskos C., Katsiari C.G., Daniil Z., Gourgoulianis K., Bogdanos D.P., Sakkas L.I.	en
dc.date.accessioned	2023-01-31T08:45:36Z
dc.date.available	2023-01-31T08:45:36Z
dc.date.issued	2019
dc.identifier	10.31138/mjr.30.3.186
dc.identifier.issn	24593516
dc.identifier.uri	http://hdl.handle.net/11615/75328
dc.description.abstract	Anti-synthetase syndrome is an autoimmune disorder characterized by the presence of autoantibodies against aminoacyl transfer RNA (tRNA) synthetases, and myositis, interstitial lung disease (ILD), arthritis, fever and Raynaud's phenomenon (RP). We present a 54-year-old woman, who complained of fatigue, low-grade fever, myalgias, arthralgias, RP and dyspnoea on exertion. Chest CT scan revealed features of interstitial lung disease. Due to rapid deterioration of her lung function, she required oxygen support. The patient did not respond to empiric treatment with antibiotics. Autoantibody testing was remarkable for ANA positivity (1/160) and high-titre anti-Jo1 positivity. A diagnosis of anti-synthetase syndrome was made and the patient was placed on high-dose corticosteroids and rituximab with significant improvement. At 1-year follow up, she remains in good condition, without the need for oxygen supplementation. © Kourkouni E, Mitsogiannis G, Simopoulou T, Liaskos C, Katsiari CG, Daniil Z, Gourgoulianis K, Bogdanos DP, Sakkas LI.	en
dc.language.iso	en	en
dc.source	Mediterranean Journal of Rheumatology	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114279136&doi=10.31138%2fmjr.30.3.186&partnerID=40&md5=762c094f036a5ec585a2c5676dd73d8e
dc.subject	antibody	en
dc.subject	antinuclear antibody	en
dc.subject	bronchodilating agent	en
dc.subject	C reactive protein	en
dc.subject	clarithromycin	en
dc.subject	cotrimoxazole	en
dc.subject	creatine kinase	en
dc.subject	Jo 1 antibody	en
dc.subject	methylprednisolone	en
dc.subject	moxifloxacin	en
dc.subject	oseltamivir	en
dc.subject	oxygen	en
dc.subject	piperacillin plus tazobactam	en
dc.subject	prednisolone	en
dc.subject	rituximab	en
dc.subject	Ro52 antibody	en
dc.subject	unclassified drug	en
dc.subject	adult	en
dc.subject	allergic pneumonitis	en
dc.subject	antisynthetase syndrome	en
dc.subject	arterial oxygen saturation	en
dc.subject	arthralgia	en
dc.subject	arthritis	en
dc.subject	Article	en
dc.subject	autoimmune disease	en
dc.subject	bronchiectasis	en
dc.subject	case report	en
dc.subject	Caucasian	en
dc.subject	clinical article	en
dc.subject	computer assisted tomography	en
dc.subject	differential diagnosis	en
dc.subject	drug dose reduction	en
dc.subject	drug megadose	en
dc.subject	dyspnea	en
dc.subject	fatigue	en
dc.subject	female	en
dc.subject	fever	en
dc.subject	follow up	en
dc.subject	forced expiratory volume	en
dc.subject	forced vital capacity	en
dc.subject	human	en
dc.subject	hypoxia	en
dc.subject	interstitial lung disease	en
dc.subject	laboratory test	en
dc.subject	lung disease	en
dc.subject	lung function test	en
dc.subject	lung infiltrate	en
dc.subject	medical history	en
dc.subject	middle aged	en
dc.subject	myalgia	en
dc.subject	myositis	en
dc.subject	oxygen therapy	en
dc.subject	prescription	en
dc.subject	Raynaud phenomenon	en
dc.subject	respiratory tract infection	en
dc.subject	rheumatic disease	en
dc.subject	rheumatoid arthritis	en
dc.subject	sarcoidosis	en
dc.subject	Sjoegren syndrome	en
dc.subject	systemic lupus erythematosus	en
dc.subject	systemic sclerosis	en
dc.subject	tachypnea	en
dc.subject	thorax radiography	en
dc.subject	vasculitis	en
dc.subject	Greek Rheumatology Society and Professional Association of Rheumatologists	en
dc.title	Interstitial lung disease in anti-synthetase syndrome	en
dc.type	journalArticle	en

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Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

Tsatsakis A., Calina D., Falzone L., Petrakis D., Mitrut R., Siokas V., Pennisi M., Lanza G., Libra M., Doukas S.G., Doukas P.G., Kavali L., Bukhari A., Gadiparthi C., Vageli D.P., Kofteridis D.P., Spandidos D.A., Paoliello M.M.B., Aschner M., Docea A.O. (2020)

Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory ...

Interstitial lung disease in anti-synthetase syndrome

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