dc.creator | Kosinski C., Herzig D., Laesser C.I., Nakas C.T., Melmer A., Vogt A., Vogt B., Laimer M., Bally L., Stettler C. | en |
dc.date.accessioned | 2023-01-31T08:44:24Z | |
dc.date.available | 2023-01-31T08:44:24Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.2337/dc19-2250 | |
dc.identifier.issn | 01495992 | |
dc.identifier.uri | http://hdl.handle.net/11615/75146 | |
dc.description.abstract | OBJECTIVE While the adjustment of insulin is an established strategy to reduce the risk of exercise-associated hypoglycemia for individuals with type 1 diabetes, it is not easily feasible for those treated with ultra-long-acting basal insulin. The current study determined whether pre-exercise intake of fructose attenuates the risk of exercise-induced hypoglycemia in individuals with type 1 diabetes using insulin degludec. RESEARCH DESIGN AND METHODS Fourteen male adults with type 1 diabetes completed two 60-min aerobic cycling sessions with or without prior intake (30 min) of 20 g of fructose, in a randomized two-period crossover design. Exercise was performed in the morning in a fasted state without prior insulin reduction and after 48 h of standardized diet. The primary outcome was time to hypoglycemia (plasma glucose ≤3.9 mmol/L) during exercise. RESULTS Intake of fructose resulted in one hypoglycemic event at 60 min compared with six hypoglycemic events at 27.5 ± 9.4 min of exercise in the control condition, translating into a risk reduction of 87.8% (hazard ratio 0.12 [95% CI 0.02, 0.66]; P = 0.015). Mean plasma glucose during exercise was 7.3 ± 1.4 mmol/L with fructose and 5.5 ± 1.1 mmol/L in the control group (P < 0.001). Lactate levels were higher at rest in the 30 min following fructose intake (P < 0.001) but were not significantly different from the control group during exercise (P = 0.32). Substrate oxidation during exercise did not significantly differ between the conditions (P = 0.73 for carbohydrate and P = 0.48 for fat oxidation). Fructose was well tolerated. CONCLUSIONS Pre-exercise intake of fructose is an easily feasible, effective, and well-tolerated strategy to alleviate the risk of exercise-induced hypoglycemia while avoiding hyperglycemia in individuals with type 1 diabetes on ultra-long-acting insulin. © 2020 by the American Diabetes Association. | en |
dc.language.iso | en | en |
dc.source | Diabetes Care | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090098683&doi=10.2337%2fdc19-2250&partnerID=40&md5=03ab13a5f51030302cfec934f20a20b7 | |
dc.subject | fructose | en |
dc.subject | glucose | en |
dc.subject | insulin degludec | en |
dc.subject | insulin degludec | en |
dc.subject | fructose | en |
dc.subject | long acting insulin | en |
dc.subject | adult | en |
dc.subject | aerobic exercise | en |
dc.subject | Article | en |
dc.subject | clinical article | en |
dc.subject | clinical effectiveness | en |
dc.subject | clinical outcome | en |
dc.subject | controlled study | en |
dc.subject | crossover procedure | en |
dc.subject | cycling | en |
dc.subject | diet | en |
dc.subject | drug dose reduction | en |
dc.subject | exercise | en |
dc.subject | feasibility study | en |
dc.subject | fructose intake | en |
dc.subject | glucose blood level | en |
dc.subject | human | en |
dc.subject | hypoglycemia | en |
dc.subject | insulin dependent diabetes mellitus | en |
dc.subject | lipid oxidation | en |
dc.subject | male | en |
dc.subject | open study | en |
dc.subject | randomized controlled trial | en |
dc.subject | risk factor | en |
dc.subject | risk reduction | en |
dc.subject | Conference Paper | en |
dc.subject | blood | en |
dc.subject | diet restriction | en |
dc.subject | dose response | en |
dc.subject | drug administration | en |
dc.subject | drug effect | en |
dc.subject | exercise | en |
dc.subject | hypoglycemia | en |
dc.subject | insulin dependent diabetes mellitus | en |
dc.subject | physiology | en |
dc.subject | proof of concept | en |
dc.subject | young adult | en |
dc.subject | Adult | en |
dc.subject | Bicycling | en |
dc.subject | Blood Glucose | en |
dc.subject | Cross-Over Studies | en |
dc.subject | Diabetes Mellitus, Type 1 | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Exercise | en |
dc.subject | Fasting | en |
dc.subject | Fructose | en |
dc.subject | Humans | en |
dc.subject | Hypoglycemia | en |
dc.subject | Insulin, Long-Acting | en |
dc.subject | Male | en |
dc.subject | Proof of Concept Study | en |
dc.subject | Young Adult | en |
dc.subject | American Diabetes Association Inc. | en |
dc.title | A single load of fructose attenuates the risk of exercise-induced hypoglycemia in adults with type 1 diabetes on ultra-long-acting basal insulin: A randomized, open-label, crossover proof-of-principle study | en |
dc.type | journalArticle | en |