Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin
Ημερομηνία
2016Γλώσσα
en
Λέξη-κλειδί
Επιτομή
There is currently lack of information on the changes of acute phase proteins (APP) and antioxidant markers and their clinical relevance as treatment response indicators in canine monocytic ehrlichiosis (CME). The objective of this study was to investigate the patterns of C-reactive protein (CRP), haptoglobin (Hp), ferritin and paraoxonase-1 (PON-1) during treatment of dogs with acute CME with rifampicin. Blood serum samples from ten Beagle dogs with experimental acute CME were retrospectively examined. Five dogs (Group A) were treated with rifampicin (10 mg/Kg/24 h), per os, for 3 weeks and 5 dogs (Group B) received no treatment (infected controls). Two Beagle dogs served as uninfected controls. Blood serum samples were serially examined prior to Ehrlichia canis inoculation and on post-inoculation days 14, 21, 28, 35 and 42. Significant changes of CRP, Hp, ferritin and PON-1 values were found in the majority of infected dogs. However, their concentrations did not differ between the two groups during the treatment observation period. The results of this study indicate that although several APP and PON-1 tend to significantly change in the majority of dogs with acute CME, they were of limited clinical relevance as treatment response indicators in this experimental setting. © 2016 Elsevier B.V.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Seroprevalence and risk factors associated with Ehrlichia canis in a hospital canine population
Chochlios T.A., Angelidou E., Kritsepi-Konstantinou M., Koutinas C.K., Mylonakis M.E. (2019)Background: Ehrlichia canis (E canis) infection has been documented in a few small canine case series in Greece. However, there is limited information on the prevalence of exposure to, or the potential risk factors associated ... -
Canine pancytopoenia in a Mediterranean region: a retrospective study of 119 cases (2005 to 2013)
Frezoulis P.S., Angelidou E., Karnezi D., Oikonomidis I.L., Kritsepi-Konstantinou M., Kasabalis D., Mylonakis M.E. (2017)Objectives: To further clarify the causes of pancytopoenia and to investigate whether underlying cause or severity were associated with survival in an area endemic for vector-borne pathogens. Methods: Retrospective review ... -
Quantitative and Morphological Blood Cell Findings Associated with the Presence of Antigen and/or Antibodies against Anaplasma phagocytophilum in Sheep
Katsogiannou E.G., Katsoulos P.D., Christodoulopoulos G., Polizopoulou Z.S., Papadakis S.M., Kokkinaki K.C., Billinis C., Boutsini S., Stougiou D., Athanasiou L.V. (2021)Anaplasma phagocytophilum is the causative agent of a disease known as tick borne fever in sheep, although fever is not always present. Due to inconclusive clinical signs, diagnosis is based on the cytological or molecular ...