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Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting
dc.creator | Grundler F., Mesnage R., Goutzourelas N., Tekos F., Makri S., Brack M., Kouretas D., Wilhelmi de Toledo F. | en |
dc.date.accessioned | 2023-01-31T08:27:21Z | |
dc.date.available | 2023-01-31T08:27:21Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1016/j.fct.2020.111701 | |
dc.identifier.issn | 02786915 | |
dc.identifier.uri | http://hdl.handle.net/11615/73729 | |
dc.description.abstract | Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves metabolic health and enhanced the total antioxidant capacity. The present study investigated the influence of a 10-day fasting on markers of the redox status in 109 subjects. Reducing power, 2,2’-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation(ABTS) radical scavenging capacity, and hydroxyl radical scavenging capacity increased significantly, and indicated an increase of circulating antioxidant levels. No differences were detected in superoxide scavenging capacity, protein carbonyls, and superoxide dismutase when measured at baseline and after 10 days of fasting. These findings were concomitant to a decrease in blood glucose, insulin, glycated hemoglobin (HbA1c), total cholesterol, low-density lipoprotein (LDL) and triglycerides as well as an increase in total cholesterol/high-density lipoprotein (HDL) ratio. In addition, the well-being index as well as the subjective energy levels increased, documenting a good tolerability. There was an interplay between redox and metabolic parameters since lipid peroxidation baseline levels (thiobarbituric acid reactive substances [TBARS]) affected the ability of long-term fasting to normalize lipid levels. A machine learning model showed that a combination of antioxidant parameters measured at baseline predicted the efficiency of the fasting regimen to decrease LDL levels. In conclusion, it was demonstrated that long-term fasting enhanced the endogenous production of antioxidant molecules, that act protectively against free radicals, and in parallel improved the metabolic health status. Our results suggest that the outcome of long-term fasting strategies could be depending on the baseline values of the antioxidative and metabolic status of subjects. © 2020 Elsevier Ltd | en |
dc.language.iso | en | en |
dc.source | Food and Chemical Toxicology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090152787&doi=10.1016%2fj.fct.2020.111701&partnerID=40&md5=b5b9c0cbf9751fe4e272d831042f50f5 | |
dc.subject | biological marker | en |
dc.subject | carbonyl derivative | en |
dc.subject | cholesterol | en |
dc.subject | glucose | en |
dc.subject | hemoglobin A1c | en |
dc.subject | high density lipoprotein | en |
dc.subject | insulin | en |
dc.subject | low density lipoprotein | en |
dc.subject | superoxide dismutase | en |
dc.subject | thiobarbituric acid reactive substance | en |
dc.subject | triacylglycerol | en |
dc.subject | biological marker | en |
dc.subject | scavenger | en |
dc.subject | ABTS radical scavenging assay | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cholesterol blood level | en |
dc.subject | controlled study | en |
dc.subject | energy metabolism | en |
dc.subject | fasting | en |
dc.subject | female | en |
dc.subject | glucose blood level | en |
dc.subject | hemoglobin blood level | en |
dc.subject | human | en |
dc.subject | hydroxyl radical scavenging assay | en |
dc.subject | insulin blood level | en |
dc.subject | lipid peroxidation | en |
dc.subject | lipoprotein blood level | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | metabolism | en |
dc.subject | middle aged | en |
dc.subject | oxidation reduction state | en |
dc.subject | oxidative stress | en |
dc.subject | triacylglycerol blood level | en |
dc.subject | adolescent | en |
dc.subject | aged | en |
dc.subject | blood | en |
dc.subject | Coronavirus infection | en |
dc.subject | diet restriction | en |
dc.subject | lipid metabolism | en |
dc.subject | machine learning | en |
dc.subject | metabolism | en |
dc.subject | obesity | en |
dc.subject | oxidative stress | en |
dc.subject | pandemic | en |
dc.subject | physiology | en |
dc.subject | virus pneumonia | en |
dc.subject | young adult | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Biomarkers | en |
dc.subject | Coronavirus Infections | en |
dc.subject | Fasting | en |
dc.subject | Female | en |
dc.subject | Free Radical Scavengers | en |
dc.subject | Humans | en |
dc.subject | Lipid Metabolism | en |
dc.subject | Lipid Peroxidation | en |
dc.subject | Machine Learning | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Obesity | en |
dc.subject | Oxidative Stress | en |
dc.subject | Pandemics | en |
dc.subject | Pneumonia, Viral | en |
dc.subject | Young Adult | en |
dc.subject | Elsevier Ltd | en |
dc.title | Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting | en |
dc.type | journalArticle | en |
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