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Association between Helicobacter pylori infection and Guillain-Barré Syndrome: A meta-analysis
dc.creator | Dardiotis E., Sokratous M., Tsouris Z., Siokas V., Mentis A.-F.A., Aloizou A.-M., Michalopoulou A., Bogdanos D.P., Xiromerisiou G., Deretzi G., Kountouras J., Hadjigeorgiou G.M. | en |
dc.date.accessioned | 2023-01-31T07:51:13Z | |
dc.date.available | 2023-01-31T07:51:13Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1111/eci.13218 | |
dc.identifier.issn | 00142972 | |
dc.identifier.uri | http://hdl.handle.net/11615/73102 | |
dc.description.abstract | Background: Helicobacter pylori (H pylori) is a Gram-negative bacterium, considered to trigger autoimmune gastrointestinal disorders. This pathogen has also been linked to the autoimmune sequelae in extra-gastrointestinal diseases and peripheral neuropathies. Guillain-Barré syndrome (GBS) is a serious autoimmune demyelinating disorder of peripheral nerves, usually with a post-infectious onset. About 30% of cases of GBS attributed to by Campylobacter jejuni, so, H pylori, could be also involved. Growing evidence suggests the likely involvement of H pylori infection in the development of GBS. The aim of the current study was to therefore estimate the prevalence of H pylori antibodies in GBS. Methods: A search of the literature was performed, using the PUBMED database, until December 2018. Data were extracted from six case-control studies, and a stratification analysis was conducted according to cerebrospinal fluid (CSF) or serum detection material. Results: Among 29 records found, 6 studies met in the inclusion criteria for the meta-analysis. In the CSF subgroup, 105 participants were involved (40 GBS patients and 65 controls), while the serum subgroup included 325 participants (152 GBS and 173 controls). Data were combined using a fixed-effects model. Anti-H pylori IgG were significantly more prevalent in GBS patients compared to controls, in both CSF (95% CI: 9.66-186.56, OR: 42.45, Pz <.00001) and serum (95% CI: 1.30-4.11, OR: 2.31, Pz:.004) subgroups. Conclusion: The present meta-analysis showed a strong association between GBS and the presence of H pylori antibodies, especially in CSF, thereby suggesting a role of H pylori infection in the pathophysiology of GBS. © 2020 Stichting European Society for Clinical Investigation Journal Foundation | en |
dc.language.iso | en | en |
dc.source | European Journal of Clinical Investigation | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082189493&doi=10.1111%2feci.13218&partnerID=40&md5=38b1c32da57f0a3ca46813e795433ad4 | |
dc.subject | bacterium antibody | en |
dc.subject | Helicobacter pylori antibody | en |
dc.subject | immunoglobulin G antibody | en |
dc.subject | unclassified drug | en |
dc.subject | bacterium antibody | en |
dc.subject | immunoglobulin G | en |
dc.subject | antibody blood level | en |
dc.subject | Article | en |
dc.subject | cerebrospinal fluid | en |
dc.subject | disease association | en |
dc.subject | Guillain Barre syndrome | en |
dc.subject | Helicobacter infection | en |
dc.subject | human | en |
dc.subject | meta analysis | en |
dc.subject | prevalence | en |
dc.subject | priority journal | en |
dc.subject | blood | en |
dc.subject | Guillain Barre syndrome | en |
dc.subject | Helicobacter infection | en |
dc.subject | Helicobacter pylori | en |
dc.subject | immunology | en |
dc.subject | Antibodies, Bacterial | en |
dc.subject | Guillain-Barre Syndrome | en |
dc.subject | Helicobacter Infections | en |
dc.subject | Helicobacter pylori | en |
dc.subject | Humans | en |
dc.subject | Immunoglobulin G | en |
dc.subject | Blackwell Publishing Ltd | en |
dc.title | Association between Helicobacter pylori infection and Guillain-Barré Syndrome: A meta-analysis | en |
dc.type | journalArticle | en |
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