Small airways’ function in Obstructive Sleep Apnea-Hypopnea Syndrome
Datum
2021Language
en
Schlagwort
Zusammenfassung
Introduction and objectives: Most of the studies of the pathophysiology of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) focus on the collapsibility and obstruction of the upper airways. The aim of our study was the investigation of small airways’ function in patients with OSAHS. Materials and methods: We studied 23 patients (mean age, 51.6 years) diagnosed with mild to severe OSAHS, without comorbidities and 8 controls (mean age, 45.9 years). All subjects underwent full polysomnography sleep study; spirometry and maximum flow/volume curves while breathing room air and a mixture of 80%He-20%O2. The volume of equal flows (VisoV⋅) of the two curves and the difference of flows at 50% of FVC (ΔV˙max50) were calculated, as indicates of small airways’ function. Results: The results showed that VisoV⋅ was significantly increased in patients with OSAHS compared with controls (18.79 ± 9.39 vs. 4.72 ± 4.68, p = 0.004). No statistically significantly difference was found in ΔV˙max50% (p = 0.551); or the maximum Expiratory flow at 25–75% of FVC (p = 0.067) and the maximum expiratory flow at 50% of FVC (p = 0.174) breathing air. Conclusions: We conclude that at the time of the diagnosis of OSAHS, the function of the small airways is affected. This could be due to breathing at low lung volumes and the cyclic closure/opening of the small airways and may affect the natural history of OSAHS. The findings could lead to new therapeutic implications, targeting directly the small airways. © 2020 Sociedade Portuguesa de Pneumologia
Collections
Verwandte Dokumente
Anzeige der Dokumente mit ähnlichem Titel, Autor, Urheber und Thema.
-
A systematic review, meta-analysis and meta-regression on the effects of carbohydrates on sleep
Vlahoyiannis A., Giannaki C.D., Sakkas G.K., Aphamis G., Andreou E. (2021)This study aimed to assess the effects of quantity, quality and periodization of carbohydrates consumption on sleep. PubMed, SCOPUS and Cochrane Library were searched through October 2020. Data were pooled using random-effects ... -
Association Between Sleep Disturbances and Frailty: Evidence From a Population-Based Study
Balomenos V., Ntanasi E., Anastasiou C.A., Charisis S., Velonakis G., Karavasilis E., Tsapanou A., Yannakoulia M., Kosmidis M.H., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. (2021)Objective: To explore the association between both self-reported quality and quantity sleep characteristics and frailty status in a large non–sex-specific population of older individuals in Greece. Design: Cross-sectional ... -
C-reactive protein as a potential biomarker of residual obstructive sleep apnea following adenotonsillectomy in children
Bhattacharjee R., Kheirandish-Gozal L., Kaditis A.G., Verhulst S.L., Gozal D. (2016)Study Objectives: Adenotonsillectomy (AT) is first-line treatment for pediatric obstructive sleep apnea (OSA), with most children having improvements in polysomnography (PSG). However, many children have residual OSA ...