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C-reactive protein as a potential biomarker of residual obstructive sleep apnea following adenotonsillectomy in children
dc.creator | Bhattacharjee R., Kheirandish-Gozal L., Kaditis A.G., Verhulst S.L., Gozal D. | en |
dc.date.accessioned | 2023-01-31T07:38:14Z | |
dc.date.available | 2023-01-31T07:38:14Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.5665/sleep.5428 | |
dc.identifier.issn | 01618105 | |
dc.identifier.uri | http://hdl.handle.net/11615/71637 | |
dc.description.abstract | Study Objectives: Adenotonsillectomy (AT) is first-line treatment for pediatric obstructive sleep apnea (OSA), with most children having improvements in polysomnography (PSG). However, many children have residual OSA following AT as determined through PSG. Identification of a biomarker of residual disease would be clinically meaningful to detect children at risk. We hypothesize serum high-sensitivity C-reactive protein (hsCRP), an inflammatory biomarker, is predictive of residual OSA following AT. Methods: PSG was performed both preoperatively and postoperatively on children undergoing AT for the diagnosis of OSA. HsCRP serum concentrations were determined in all children pre-AT, and in most children post-AT. Resolution of OSA after AT was defined by a post-AT apnea-hypopnea index (AHI) < 1.5/h total sleep time (TST). Residual OSA was defined as a post-AT AHI > 5/h TST, which is considered clinically significant. Results: AT significantly improved the AHI from 15.9 ± 16.4 to 4.1 ± 5.3/h TST in 182 children (P < 0.001). Of 182 children, residual OSA (post-AT AHI > 5) was seen in 46 children (25%). Among children who had hsCRP levels measured pre- And post-AT (n = 155), mean hsCRP levels pre-AT were 0.98 ± 1.91 mg/L and were significantly reduced post-AT (0.63 ± 2.24 mg/dL; P = 0.011). Stratification into post-AT AHI groups corresponding to < 1.5/h TST, 1.5/h TST < AHI < 5/h TST, and AHI > 5/h TST revealed post-AT hsCRP levels of 0.09 ± 0.12, 0.57 ± 2.28, and 1.49 ± 3.34 mg/L with statistical significance emerging comparing residual AHI > 5/h TST compared to post-AT AHI < 1.5/h TST (P = 0.006). Hierarchical multivariate modeling confirmed that pre-AT AHI and post-AT hsCRP levels were most significantly associated with residual OSA. Conclusions: Even though AT improves OSA in most children, residual OSA is frequent. Assessment of post-AT hsCRP levels emerges as a potentially useful biomarker predicting residual OSA. | en |
dc.language.iso | en | en |
dc.source | Sleep | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957107494&doi=10.5665%2fsleep.5428&partnerID=40&md5=ce8fcb50192d315b3aef4b0a16a8f7dc | |
dc.subject | C reactive protein | en |
dc.subject | biological marker | en |
dc.subject | C reactive protein | en |
dc.subject | adenotonsillectomy | en |
dc.subject | adult | en |
dc.subject | apnea hypopnea index | en |
dc.subject | Article | en |
dc.subject | child | en |
dc.subject | childhood disease | en |
dc.subject | diagnostic test accuracy study | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | minimal residual disease | en |
dc.subject | obesity | en |
dc.subject | polysomnography | en |
dc.subject | postoperative period | en |
dc.subject | prediction | en |
dc.subject | preoperative period | en |
dc.subject | preschool child | en |
dc.subject | priority journal | en |
dc.subject | residual obstructive sleep apnea | en |
dc.subject | sensitivity and specificity | en |
dc.subject | sleep disordered breathing | en |
dc.subject | sleep time | en |
dc.subject | total sleep time | en |
dc.subject | adenoidectomy | en |
dc.subject | metabolism | en |
dc.subject | pathophysiology | en |
dc.subject | risk | en |
dc.subject | Sleep Apnea, Obstructive | en |
dc.subject | tonsillectomy | en |
dc.subject | Adenoidectomy | en |
dc.subject | Biomarkers | en |
dc.subject | C-Reactive Protein | en |
dc.subject | Child | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Polysomnography | en |
dc.subject | Postoperative Period | en |
dc.subject | Risk | en |
dc.subject | Sleep Apnea, Obstructive | en |
dc.subject | Tonsillectomy | en |
dc.subject | Associated Professional Sleep Societies,LLC | en |
dc.title | C-reactive protein as a potential biomarker of residual obstructive sleep apnea following adenotonsillectomy in children | en |
dc.type | journalArticle | en |
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