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dc.creatorFilippitzis F., Gourgoulianis K., Daniil Z., Bontozoglou V.en
dc.date.accessioned2023-01-31T07:37:59Z
dc.date.available2023-01-31T07:37:59Z
dc.date.issued2020
dc.identifier10.1080/02786826.2020.1759775
dc.identifier.issn02786826
dc.identifier.urihttp://hdl.handle.net/11615/71576
dc.description.abstractA dynamic, single-path model is developed for dry powder transport in the lungs. The model differentiates between particle behavior in the respiratory bronchioles and alveolar ducts on one hand and inside the alveoli on the other. In particular, it considers the alveolar volume of each generation as a mixing chamber. Air inflow to the alveoli is calculated by accounting for the deformation of airways during breathing. Particle dispersion along the respiratory tract is taken into account and mechanistic deposition rates are developed for the alveoli. Deposition by Brownian diffusion is modeled by a concentration boundary layer, whose thickness varies inversely with the intensity of mixing. The plausibility of the assumption of alveolar mixing is tested indirectly by comparison of model predictions with benchmark data of the exhaled concentration profile and of the pulmonary deposition of continuously inhaled aerosols. The observed agreement lends support to the hypothesis that alveolar mixing represents fundamental physics of the breathing process. It also supports the suggestion that alveolar mixing provides an additional axial dispersion mechanism in the acinus, which is independent of particle size and is active at zero gravity. Copyright © 2020 American Association for Aerosol Research. © 2020, © 2020 American Association for Aerosol Research.en
dc.language.isoenen
dc.sourceAerosol Science and Technologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084836151&doi=10.1080%2f02786826.2020.1759775&partnerID=40&md5=3be6359385b3532590207fa0cb8f88d7
dc.subjectAerosolsen
dc.subjectBoundary layersen
dc.subjectDeposition ratesen
dc.subjectParticle sizeen
dc.subjectBrownian diffusionen
dc.subjectComparison of modelsen
dc.subjectConcentration boundary layeren
dc.subjectConcentration profilesen
dc.subjectFundamental physicsen
dc.subjectParticle behavioren
dc.subjectParticle dispersionen
dc.subjectParticle retentionen
dc.subjectMixingen
dc.subjectaerosolen
dc.subjectairwayen
dc.subjectarticleen
dc.subjectboundary layeren
dc.subjectbronchioleen
dc.subjectdiffusionen
dc.subjectdry powderen
dc.subjectlung alveolusen
dc.subjectparticle sizeen
dc.subjectphysicsen
dc.subjectpredictionen
dc.subjectrespiratory systemen
dc.subjectthicknessen
dc.subjectweightlessnessen
dc.subjectTaylor and Francis Inc.en
dc.titleThe effect of alveolar mixing on particle retention and deposition investigated by a dynamic single-path modelen
dc.typejournalArticleen


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