Όλο το DSpace

Εμφάνιση απλής εγγραφής

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

dc.creatorFerreiro-Iglesias A., Montes A., Perez-Pampin E., Cañete J.D., Raya E., Magro-Checa C., Vasilopoulos Y., Sarafidou T., Caliz R., Ferrer M.A., Joven B., Carreira P., Balsa A., Pascual-Salcedo D., Blanco F.J., Moreno-Ramos M.J., Fernández-Nebro A., Ordóñez M.C., Alegre-Sancho J.J., Narváez J., Navarro-Sarabia F., Moreira V., Valor L., García-Portales R., Marquez A., Martin J., Gómez-Reino J.J., Gonzalez A.en
dc.date.accessioned2023-01-31T07:37:52Z
dc.date.available2023-01-31T07:37:52Z
dc.date.issued2016
dc.identifier10.1038/tpj.2015.29
dc.identifier.issn1470269X
dc.identifier.urihttp://hdl.handle.net/11615/71539
dc.description.abstractGenetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have shown association with response to TNF inhibitors (TNFi) in candidate gene studies and that we assayed here in 755 RA patients. Three of them, in the PTPRC, IL10 and CHUK genes, were significantly associated with response to TNFi. The most significant result was obtained with rs10919563 in PTPRC, which is a confirmed RA susceptibility locus. Its RA risk allele was associated with improved response (B=0.33, P=0.006). This is the second independent replication of this biomarker (P=9.08 × 10 -8 in the combined 3003 RA patients). In this way, PTPRC has become the most replicated genetic biomarker of response to TNFi. In addition, the positive but weaker replication of IL10 and CHUK should stimulate further validation studies. © 2016 Macmillan Publishers Limited.en
dc.language.isoenen
dc.sourcePharmacogenomics Journalen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928151802&doi=10.1038%2ftpj.2015.29&partnerID=40&md5=b73a1893010bec688e5c0439746f8ec5
dc.subjectadalimumaben
dc.subjectetanercepten
dc.subjectinfliximaben
dc.subjecttumor necrosis factor inhibitoren
dc.subjectantirheumatic agenten
dc.subjectCD45 antigenen
dc.subjectCHUK protein, humanen
dc.subjectgenetic markeren
dc.subjectI kappa B kinaseen
dc.subjectinterleukin 10en
dc.subjectPTPRC protein, humanen
dc.subjecttumor necrosis factoren
dc.subjectadulten
dc.subjectalleleen
dc.subjectArticleen
dc.subjectCHUK geneen
dc.subjectdrug responseen
dc.subjectfemaleen
dc.subjectgeneen
dc.subjectgene locusen
dc.subjectgene replicationen
dc.subjectgenetic susceptibilityen
dc.subjectgenotypeen
dc.subjecthumanen
dc.subjectIL10 geneen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectpriority journalen
dc.subjectPTPRC geneen
dc.subjectrheumatoid arthritisen
dc.subjectsingle nucleotide polymorphismen
dc.subjectantagonists and inhibitorsen
dc.subjectArthritis, Rheumatoiden
dc.subjectgenetic association studyen
dc.subjectgenetic markeren
dc.subjectgeneticsen
dc.subjectmiddle ageden
dc.subjectrisken
dc.subjectAdalimumaben
dc.subjectAntigens, CD45en
dc.subjectAntirheumatic Agentsen
dc.subjectArthritis, Rheumatoiden
dc.subjectFemaleen
dc.subjectGenetic Association Studiesen
dc.subjectGenetic Markersen
dc.subjectHumansen
dc.subjectI-kappa B Kinaseen
dc.subjectInfliximaben
dc.subjectInterleukin-10en
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectRisken
dc.subjectTumor Necrosis Factor-alphaen
dc.subjectNature Publishing Groupen
dc.titleReplication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritisen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής