Anti-hsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis: (ir)Relevance to disease pathogenesis
Ημερομηνία
2016Γλώσσα
en
Λέξη-κλειδί
Επιτομή
In view of published data suggesting that Helicobacter pylori (Hp) is a trigger of multiple sclerosis (MS), we assessed anti-heat shock protein 60 (hsp60)Hp antibody reactivity in 129 MS patients and 48 demograpically-matched healthy controls (HCs). Anti-Hp antibodies by ELISA were more elevated in MS than HCs but did not differ between different MS phenotypes. All anti-Hp-positive MS sera, irrespectively of their clinical phenotype, were anti-anti-hsp60 positive. Anti-hsp60 Hp seropositivity correlated with age at disease onset. In conclusion, anti-hsp60 Hp antibodies are present in all anti-Hp positive MS patients, and their relevance to disease pathogenesis is questionable. © 2016 Elsevier B.V.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Association between Helicobacter pylori infection and Guillain-Barré Syndrome: A meta-analysis
Dardiotis E., Sokratous M., Tsouris Z., Siokas V., Mentis A.-F.A., Aloizou A.-M., Michalopoulou A., Bogdanos D.P., Xiromerisiou G., Deretzi G., Kountouras J., Hadjigeorgiou G.M. (2020)Background: Helicobacter pylori (H pylori) is a Gram-negative bacterium, considered to trigger autoimmune gastrointestinal disorders. This pathogen has also been linked to the autoimmune sequelae in extra-gastrointestinal ... -
Antigen-specific humoral responses against Helicobacter pylori in patients with systemic sclerosis
Efthymiou G., Liaskos C., Simopoulou T., Marou E., Patrikiou E., Scheper T., Meyer W., Daoussis D., Sakkas L.I., Bogdanos D.P. (2020)Helicobacter pylori (Hp) is a likely trigger of systemic sclerosis (SSc), but systemic antigen-specific antibody (Ab) responses in a well-defined cohort of SSc patients have not been thoroughly assessed. Line immunoassay ... -
Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
Efthymiou G., Dardiotis E., Liaskos C., Marou E., Tsimourtou V., Rigopoulou E.I., Scheper T., Daponte A., Meyer W., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. (2017)To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance ...