Efficacy of local administration of tranexamic acid for blood salvage in patients undergoing intertrochanteric fracture surgery
Autore
Drakos A., Raoulis V., Karatzios K., Doxariotis N., Kontogeorgakos V., Malizos K., Varitimidis S.E.Data
2016Language
en
Soggetto
Abstract
Objectives: The primary aim of this study was to assess whether local administration of tranexamic acid (TXA) reduced the need for a blood transfusion in elderly patients treated with an intramedullary (IM) nail for an intertrochanteric fracture. Design: Randomized prospective trial. Setting: Academic level 1 trauma center. Patients: Two hundred patients (200 fractures) over 65 years with an intertrochanteric fracture treated by IM nail between April 1, 2012, and March 31, 2014. Intervention: Subfascial administration of 3 g of TXA around the fracture site at the end of the surgical procedure, versus a control group without TXA. Follow-up ranged from 12 to 24 months. Main Outcome Measures: Group differences in number of transfused packed red blood cell (PRBC) units, and hematocrit, hemoglobin, and platelet count. Results: There was a 43% reduction in transfusion requirements in the TXA group (P < 0.01). Twenty-seven units of PRBC were transfused in 22/100 patients in the TXA group, whereas 48 PRBC units were transfused in 29/100 patients in control group. There was no difference between the 2 groups in terms of late complications and overall mortality rate. Conclusions: Subfascial administration of TXA around the fracture site in elderly patients undergoing IM nailing for intertrochanteric fractures is safe and cost-effective. A significant reduction in blood loss and transfused blood units, and health care cost can be achieved. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. © 2016 Wolters Kluwer Health, Inc.
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