The effect of preemptive use of pregabalin on postoperative morphine consumption and analgesia levels after laparoscopic colorectal surgery: a controlled randomized trial
Author
Baloyiannis I., Theodorou E., Sarakatsianou C., Georgopoulou S., Perivoliotis K., Tzovaras G.Date
2020Language
en
Keyword
Abstract
Purpose: In order to reduce postoperative opioid administration and pain levels in patients submitted to laparoscopic colectomy, we assessed the efficacy of preemptive use of pregabalin (PG), as part of a multimodal analgesia scheme, in a randomized controlled trial setting. Methods: Overall, fifty adult patients scheduled for elective laparoscopic colectomy were included and randomized in our trial. In the experimental group, 23 patients received preoperatively 2 doses of 150 mg PG per os, whereas the control group consisted of 27 cases, where a matching to PG placebo was administered at the same scheme. The two groups had identical analgesia and anesthesia regimens otherwise. Our study endpoints included postoperative morphine consumption, postoperative pain, and complication rates. Results: Patients in the PG group displayed a significantly reduced morphine consumption at 8 h, 24 h, and 48 h postoperatively. The two groups were comparable in terms of postoperative pain (rest and movement assessment) and side effects. Conclusions: The preoperative addition of PG resulted in a significant reduction of the postoperative opioid consumption in patients undergoing laparoscopic colectomy. However, an association with the postoperative pain scores was not identified. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Surgical and functional outcome of olfactory groove meningiomas: Lessons from the past experience and strategy development
Fountas K.N., Hadjigeorgiou G.F., Kapsalaki E.Z., Paschalis T., Rizea R., Ciurea A.V. (2018)Object: Olfactory groove meningiomas (OGMs) constitute a unique subset of intracranial meningiomas, since they usually remain clinically silent for a long period of time, and they may be of large size upon their diagnosis. ... -
Multimodal Analgesia in Spine Surgery: An Umbrella Review
Ntalouka M.P., Brotis A.G., Bareka M.V., Stertsou E.S., Fountas K.N., Arnaoutoglou E.M. (2021)Objective: In recent years, there has been a growing interest regarding the implementation of multimodal analgesia as an important component of the ideal perioperative patient management. The aim of the current umbrella ... -
Palliative surgical bypass is superior to palliative endoscopic stenting in patients with malignant gastric outlet obstruction: systematic review and meta-analysis
Mintziras I., Miligkos M., Wächter S., Manoharan J., Bartsch D.K. (2019)Background: Gastrojejunostomy (GJ) and self-expanding metal stents (SEMS) are the two most common palliative treatment options for patients with malignant gastric outlet obstruction (GOO). Randomised trials and retrospective ...