| dc.creator | Bally L., Bovet C., Nakas C.T., Zueger T., Prost J.-C., Nuoffer J.-M., Leichtle A.B., Fiedler G.M., Stettler C. | en |
| dc.date.accessioned | 2023-01-31T07:35:34Z | |
| dc.date.available | 2023-01-31T07:35:34Z | |
| dc.date.issued | 2017 | |
| dc.identifier | 10.1007/s11306-017-1217-8 | |
| dc.identifier.issn | 15733882 | |
| dc.identifier.uri | http://hdl.handle.net/11615/71085 | |
| dc.description.abstract | Introduction: Exercise-associated metabolism in type 1 diabetes (T1D) remains under-studied due to the complex interplay between exogenous insulin, counter-regulatory hormones and insulin-sensitivity. Objective: To identify the metabolic differences induced by two exercise modalities in T1D using ultra high-performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC–HRMS) based metabolomics. Methods: Twelve T1D adults performed intermittent high-intensity (IHE) and continuous-moderate-intensity (CONT) exercise. Serum samples were analysed by UHPLC–HRMS. Results: Metabolic profiling of IHE and CONT highlighted exercise-induced changes in purine and acylcarnitine metabolism. Conclusion: IHE may increase beta-oxidation through higher ATP-turnover. UHPLC–HRMS based metabolomics as a data-driven approach without an a priori hypothesis may help uncover distinctive metabolic effects during exercise in T1D. Clinical trial registration number is www.clinicaltrials.gov: NCT02068638. © 2017, Springer Science+Business Media New York. | en |
| dc.language.iso | en | en |
| dc.source | Metabolomics | en |
| dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019257056&doi=10.1007%2fs11306-017-1217-8&partnerID=40&md5=8fa2fc96f9617b01cb3eec0ca3b1cf11 | |
| dc.subject | acylcarnitine | en |
| dc.subject | adenosine | en |
| dc.subject | adenosine triphosphate | en |
| dc.subject | carnitine | en |
| dc.subject | guanosine | en |
| dc.subject | hypoxanthine | en |
| dc.subject | inosine | en |
| dc.subject | purine | en |
| dc.subject | uric acid | en |
| dc.subject | xanthine | en |
| dc.subject | adult | en |
| dc.subject | Article | en |
| dc.subject | clinical article | en |
| dc.subject | exercise | en |
| dc.subject | fatty acid oxidation | en |
| dc.subject | human | en |
| dc.subject | insulin dependent diabetes mellitus | en |
| dc.subject | male | en |
| dc.subject | mass spectrometry | en |
| dc.subject | metabolism | en |
| dc.subject | metabolomics | en |
| dc.subject | randomized controlled trial (topic) | en |
| dc.subject | ultra performance liquid chromatography | en |
| dc.subject | Springer New York LLC | en |
| dc.title | A metabolomics approach to uncover effects of different exercise modalities in type 1 diabetes | en |
| dc.type | journalArticle | en |
