Curcumin for the management of periodontitis and early ACPA-positive rheumatoid arthritis: Killing two birds with one stone
dc.creator | Asteriou E., Gkoutzourelas A., Mavropoulos A., Katsiari C., Sakkas L.I., Bogdanos D.P. | en |
dc.date.accessioned | 2023-01-31T07:33:47Z | |
dc.date.available | 2023-01-31T07:33:47Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3390/nu10070908 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | http://hdl.handle.net/11615/70894 | |
dc.description.abstract | We propose curcumin as a preventive measure to avoid/manage periodontitis (PD), and as a natural immunosuppressant for rheumatoid arthritis (RA). PD, mainly caused by Porphyromonas gingivalis forming biofilm and leading to tooth decay, is a major public health issue and a risk factor for the development of RA in humans. P. gingivalis is able to trigger experimental autoimmune arthritis in animal models and in humans can induce citrullinated peptides, which not only are a source of anti-citrullinated antibodies (ACPAs), but also participate in autoreactive responses and disease development. Curcumin appears to have efficient anti-bacterial activity against P. gingivalis infection and biofilm formation. In addition to antibacterial, anti-oxidant, and anti-inflammatory action, curcumin exerts unique immunosuppressant properties via the inhibition of Th17 pro-inflammatory responses and promotion of regulatory T cells, thus suppressing autoimmunity. We introduce curcumin as a natural product for the management of both PD and RA-related autoreactivity, possibly also as a preventive measure in early RA or individuals at high risk to develop RA. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Nutrients | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050374605&doi=10.3390%2fnu10070908&partnerID=40&md5=22e17830e384fd441826911b8e49ed24 | |
dc.subject | biological marker | en |
dc.subject | curcumin | en |
dc.subject | cyclic citrullinated peptide antibody | en |
dc.subject | immunosuppressive agent | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 17 | en |
dc.subject | interleukin 4 | en |
dc.subject | rheumatoid factor | en |
dc.subject | antiinfective agent | en |
dc.subject | antirheumatic agent | en |
dc.subject | curcumin | en |
dc.subject | cyclic citrullinated peptide antibody | en |
dc.subject | immunosuppressive agent | en |
dc.subject | plant extract | en |
dc.subject | Aggregatibacter actinomycetemcomitans | en |
dc.subject | antibacterial activity | en |
dc.subject | antifungal activity | en |
dc.subject | antiinflammatory activity | en |
dc.subject | antioxidant activity | en |
dc.subject | antiviral activity | en |
dc.subject | biofilm | en |
dc.subject | citrullination | en |
dc.subject | dental caries | en |
dc.subject | disease activity score | en |
dc.subject | Epstein Barr virus | en |
dc.subject | experimental allergic encephalitis | en |
dc.subject | Fusobacterium nucleatum | en |
dc.subject | Helicobacter pylori | en |
dc.subject | human | en |
dc.subject | immunological tolerance | en |
dc.subject | immunosuppressive treatment | en |
dc.subject | nonhuman | en |
dc.subject | periodontitis | en |
dc.subject | Porphyromonas gingivalis | en |
dc.subject | Prevotella intermedia | en |
dc.subject | regulatory T lymphocyte | en |
dc.subject | Review | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | Th17 cell | en |
dc.subject | traditional medicine | en |
dc.subject | Treponema denticola | en |
dc.subject | animal | en |
dc.subject | blood | en |
dc.subject | chemistry | en |
dc.subject | disease model | en |
dc.subject | drug effect | en |
dc.subject | immunology | en |
dc.subject | isolation and purification | en |
dc.subject | medicinal plant | en |
dc.subject | microbiology | en |
dc.subject | pathogenicity | en |
dc.subject | periodontitis | en |
dc.subject | phytotherapy | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | risk factor | en |
dc.subject | Animals | en |
dc.subject | Anti-Bacterial Agents | en |
dc.subject | Anti-Citrullinated Protein Antibodies | en |
dc.subject | Antirheumatic Agents | en |
dc.subject | Arthritis, Rheumatoid | en |
dc.subject | Curcumin | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Humans | en |
dc.subject | Immunosuppressive Agents | en |
dc.subject | Periodontitis | en |
dc.subject | Phytotherapy | en |
dc.subject | Plant Extracts | en |
dc.subject | Plants, Medicinal | en |
dc.subject | Porphyromonas gingivalis | en |
dc.subject | Risk Factors | en |
dc.subject | T-Lymphocytes, Regulatory | en |
dc.subject | Th17 Cells | en |
dc.subject | MDPI AG | en |
dc.title | Curcumin for the management of periodontitis and early ACPA-positive rheumatoid arthritis: Killing two birds with one stone | en |
dc.type | other | en |
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