dc.creator | Apostolou A., Kerenidi T., Michopoulos A., Gourgoulianis K.I., Noutsias M., Germenis A.E., Speletas M. | en |
dc.date.accessioned | 2023-01-31T07:32:38Z | |
dc.date.available | 2023-01-31T07:32:38Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1007/s00059-016-4510-9 | |
dc.identifier.issn | 03409937 | |
dc.identifier.uri | http://hdl.handle.net/11615/70738 | |
dc.description.abstract | Background: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of innate immune genes affect the disease phenotype and prognosis. Aim: To elucidate the contribution of common functional TLR2 and TLR4 SNPs and genotypic deficiency of the mannose-binding lectin (MBL) protein, both as single parameters and in combination, in Greek COPD patients. Results: In a cohort of 114 Greek COPD patients, we confirmed that the presence of TLR4-D299G or TLR4-T399I SNPs was significantly associated with an earlier COPD stage (p = 0.003 and p = 0.009, respectively). In comparison, the absence of any analyzed polymorphism, including those of TLR2-R753Q and genotypic MBL deficiency, was significantly associated with a more severe disease phenotype, characterized by more frequent exacerbations (p = 0.045). Conclusion: Our findings support the notion that the presence of innate immune SNPs, such as functional polymorphisms of TLRs along with MBL deficiency, might exert a protective effect on the COPD phenotype, similar with other immune-mediated disorders. © 2016, Springer Medizin Verlag Berlin. | en |
dc.language.iso | en | en |
dc.source | Herz | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000981988&doi=10.1007%2fs00059-016-4510-9&partnerID=40&md5=b7bba787709e858ba7f6637510a2fc6f | |
dc.subject | mannose binding lectin | en |
dc.subject | toll like receptor 2 | en |
dc.subject | toll like receptor 4 | en |
dc.subject | mannose binding lectin | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | chronic obstructive lung disease | en |
dc.subject | disease exacerbation | en |
dc.subject | disease severity | en |
dc.subject | female | en |
dc.subject | gene frequency | en |
dc.subject | gene linkage disequilibrium | en |
dc.subject | genetic association | en |
dc.subject | Greek (people) | en |
dc.subject | heterozygosity | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | toll like receptor 2 gene | en |
dc.subject | toll like receptor 4 gene | en |
dc.subject | chronic obstructive lung disease | en |
dc.subject | cohort analysis | en |
dc.subject | deficiency | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetics | en |
dc.subject | genotype | en |
dc.subject | immunology | en |
dc.subject | inborn error of metabolism | en |
dc.subject | innate immunity | en |
dc.subject | phenotype | en |
dc.subject | prognosis | en |
dc.subject | protection | en |
dc.subject | risk factor | en |
dc.subject | smoking | en |
dc.subject | smoking cessation | en |
dc.subject | very elderly | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Immunity, Innate | en |
dc.subject | Male | en |
dc.subject | Mannose-Binding Lectin | en |
dc.subject | Metabolism, Inborn Errors | en |
dc.subject | Phenotype | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Prognosis | en |
dc.subject | Protective Factors | en |
dc.subject | Pulmonary Disease, Chronic Obstructive | en |
dc.subject | Risk Factors | en |
dc.subject | Smoking | en |
dc.subject | Smoking Cessation | en |
dc.subject | Urban und Vogel GmbH | en |
dc.title | Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort [Assoziation zwischen TLR2-/TLR4-Gen-Polymorphismen und COPD-Phänotyp] | en |
dc.type | journalArticle | en |