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The -938C>A polymorphism in MYD88 is associated with susceptibility to tuberculosis: A pilot study

dc.creatorAggelou K., Siapati E.K., Gerogianni I., Daniil Z., Gourgoulianis K., Ntanos I., Simantirakis E., Zintzaras E., Mollaki V., Vassilopoulos G.en
dc.date.accessioned2023-01-31T07:30:28Z
dc.date.available2023-01-31T07:30:28Z
dc.date.issued2016
dc.identifier10.1155/2016/4961086
dc.identifier.issn02780240
dc.identifier.urihttp://hdl.handle.net/11615/70302
dc.description.abstractIntroduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection.The Toll- Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk. © Copyright 2016 Kalliopi Aggelou et al.en
dc.language.isoenen
dc.sourceDisease Markersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85009455691&doi=10.1155%2f2016%2f4961086&partnerID=40&md5=5bab0fdcb2c3d79001d9a56adb1d8581
dc.subjectmyeloid differentiation factor 88en
dc.subjectMYD88 protein, humanen
dc.subjectmyeloid differentiation factor 88en
dc.subjectadulten
dc.subjectArticleen
dc.subjectCaucasianen
dc.subjectconfidence intervalen
dc.subjectcontrolled studyen
dc.subjectdisease predispositionen
dc.subjectfemaleen
dc.subjectgenetic analysisen
dc.subjectgenetic risken
dc.subjectgenotypeen
dc.subjecthaplotypeen
dc.subjecthumanen
dc.subjectinheritanceen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectodds ratioen
dc.subjectpilot studyen
dc.subjectrisk factoren
dc.subjectsingle nucleotide polymorphismen
dc.subjecttuberculosisen
dc.subjectbiological modelen
dc.subjectcase control studyen
dc.subjectgene expressionen
dc.subjectgenetic association studyen
dc.subjectgenetic predispositionen
dc.subjectgeneticsen
dc.subjectisolation and purificationen
dc.subjectmicrobiologyen
dc.subjectmiddle ageden
dc.subjectmolecular typingen
dc.subjectMycobacterium tuberculosisen
dc.subjectphysiologyen
dc.subjectpromoter regionen
dc.subjectTuberculosis, Pulmonaryen
dc.subjectAdulten
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGene Expressionen
dc.subjectGenetic Association Studiesen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectModels, Geneticen
dc.subjectMolecular Typingen
dc.subjectMycobacterium tuberculosisen
dc.subjectMyeloid Differentiation Factor 88en
dc.subjectOdds Ratioen
dc.subjectPilot Projectsen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectPromoter Regions, Geneticen
dc.subjectRisk Factorsen
dc.subjectTuberculosis, Pulmonaryen
dc.subjectHindawi Limiteden
dc.titleThe -938C>A polymorphism in MYD88 is associated with susceptibility to tuberculosis: A pilot studyen
dc.typejournalArticleen


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