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dc.creatorZarkotou, O.en
dc.creatorPournaras, S.en
dc.creatorVoulgari, E.en
dc.creatorChrysos, G.en
dc.creatorPrekates, A.en
dc.creatorVoutsinas, D.en
dc.creatorThemeli-Digalaki, K.en
dc.creatorTsakris, A.en
dc.date.accessioned2015-11-23T10:54:45Z
dc.date.available2015-11-23T10:54:45Z
dc.date.issued2010
dc.identifier10.1128/jcm.02301-09
dc.identifier.issn0095-1137
dc.identifier.urihttp://hdl.handle.net/11615/34830
dc.description.abstractA matched 1: 3 case-control study investigated factors predicting colistin-resistant versus colistin-susceptible KPC-producing Klebsiella pneumoniae acquisition and its impact on patient outcomes. Case patients were more often admitted from other institutions (P = 0.019) and had longer therapy with beta-lactam/beta-lactamase inhibitors (P = 0.002) and higher overall mortality (P = 0.05). All 52 study isolates were clonally related, suggesting horizontal dissemination. None of these parameters independently predicted colistin resistance, which probably occurred in a susceptible KPC-KP strain that was subsequently disseminated horizontally.en
dc.sourceJournal of Clinical Microbiologyen
dc.source.uri<Go to ISI>://WOS:000278118100050
dc.subjectPOLYMYXIN-Ben
dc.subjectINFECTIONSen
dc.subjectSPREADen
dc.subjectTHREATen
dc.subjectGREECEen
dc.subjectMicrobiologyen
dc.titleRisk Factors and Outcomes Associated with Acquisition of Colistin-Resistant KPC-Producing Klebsiella pneumoniae: a Matched Case-Control Studyen
dc.typejournalArticleen


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