dc.creator | Zarkotou, O. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Voulgari, E. | en |
dc.creator | Chrysos, G. | en |
dc.creator | Prekates, A. | en |
dc.creator | Voutsinas, D. | en |
dc.creator | Themeli-Digalaki, K. | en |
dc.creator | Tsakris, A. | en |
dc.date.accessioned | 2015-11-23T10:54:45Z | |
dc.date.available | 2015-11-23T10:54:45Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1128/jcm.02301-09 | |
dc.identifier.issn | 0095-1137 | |
dc.identifier.uri | http://hdl.handle.net/11615/34830 | |
dc.description.abstract | A matched 1: 3 case-control study investigated factors predicting colistin-resistant versus colistin-susceptible KPC-producing Klebsiella pneumoniae acquisition and its impact on patient outcomes. Case patients were more often admitted from other institutions (P = 0.019) and had longer therapy with beta-lactam/beta-lactamase inhibitors (P = 0.002) and higher overall mortality (P = 0.05). All 52 study isolates were clonally related, suggesting horizontal dissemination. None of these parameters independently predicted colistin resistance, which probably occurred in a susceptible KPC-KP strain that was subsequently disseminated horizontally. | en |
dc.source | Journal of Clinical Microbiology | en |
dc.source.uri | <Go to ISI>://WOS:000278118100050 | |
dc.subject | POLYMYXIN-B | en |
dc.subject | INFECTIONS | en |
dc.subject | SPREAD | en |
dc.subject | THREAT | en |
dc.subject | GREECE | en |
dc.subject | Microbiology | en |
dc.title | Risk Factors and Outcomes Associated with Acquisition of Colistin-Resistant KPC-Producing Klebsiella pneumoniae: a Matched Case-Control Study | en |
dc.type | journalArticle | en |