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SEXUAL DIMORPHISM OF STRESS-RESPONSE AND IMMUNE INFLAMMATORY REACTION - THE CORTICOTROPIN-RELEASING HORMONE PERSPECTIVE

dc.creatorVamvakopoulos, N. V.en
dc.date.accessioned2015-11-23T10:53:10Z
dc.date.available2015-11-23T10:53:10Z
dc.date.issued1995
dc.identifier10.1155/s0962935195000275
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11615/34275
dc.description.abstractTHIS review highlights key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticoids, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/inflammatory reaction by steroid hormones, from the perspective of the CRH system.en
dc.source.uri<Go to ISI>://WOS:A1995RG39500001
dc.subjectAUTOIMMUNITYen
dc.subjectCORTICOTROPIN RELEASING HORMONEen
dc.subjectESTROGENSen
dc.subjectGLUCOCORTICOIDSen
dc.subjectGLUCOCORTICOID RECEPTORen
dc.subjectGONADAL STEROIDSen
dc.subjectHEAT SHOCKen
dc.subjectPROTEINSen
dc.subjectHORMONAL REGULATION OF GENE EXPRESSIONen
dc.subjectHYPOTHALAMIC-PITUITARY-ADRENAL AXISen
dc.subjectIMMUNE INFLAMMATORY REACTIONen
dc.subjectSEXUAL DIMORPHISMen
dc.subjectSTRESS RESPONSEen
dc.subjectPITUITARY-ADRENAL AXISen
dc.subjectCENTRAL NERVOUS-SYSTEMen
dc.subject3',5'-CYCLICen
dc.subjectADENOSINE-MONOPHOSPHATEen
dc.subjectGLUCOCORTICOID RECEPTOR-BINDINGen
dc.subjectWALL INDUCEDen
dc.subjectPOLYARTHRITISen
dc.subjectBLOOD MONONUCLEAR-CELLSen
dc.subjectFACTOR GENE-EXPRESSIONen
dc.subjectMESSENGER-RNA LEVELSen
dc.subjectRAT LEYDIG-CELLSen
dc.subjectACTH RELEASEen
dc.subjectCell Biologyen
dc.subjectImmunologyen
dc.titleSEXUAL DIMORPHISM OF STRESS-RESPONSE AND IMMUNE INFLAMMATORY REACTION - THE CORTICOTROPIN-RELEASING HORMONE PERSPECTIVEen
dc.typejournalArticleen


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