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Keto and Exomethylene Pyranonucleosides as Antitumor Agents

dc.creatorTsoukala, E.en
dc.creatorManta, S.en
dc.creatorKiritsis, C.en
dc.creatorKomiotis, D.en
dc.date.accessioned2015-11-23T10:52:25Z
dc.date.available2015-11-23T10:52:25Z
dc.date.issued2012
dc.identifier.issn1389-5575
dc.identifier.urihttp://hdl.handle.net/11615/34074
dc.description.abstractNucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and exomethylene pyranonucleosides, due to their high cytotoxicity in vitro and powerful inhibitory action in vivo. Their mode of action probably involves their ability to act as acceptors in a Michael-addition mechanism, while it was revealed that 5-fluorouracil nucleosides represent novel prodrugs of 5-fluorouracil targeting thymidylate synthase. The present mini review summarizes the molecular design, chemical synthesis and biological activity of keto- and exomethylene pyranonucleoside analogues.en
dc.sourceMini-Reviews in Medicinal Chemistryen
dc.source.uri<Go to ISI>://WOS:000301038800007
dc.subjectPyranonucleosidesen
dc.subjectketonucleosidesen
dc.subjectexomethylene nucleosidesen
dc.subjectoxidationen
dc.subjectWittig reactionen
dc.subjectcytotoxicityen
dc.subjectantitumor activityen
dc.subjectFLUORO-KETOPYRANOSYL NUCLEOSIDESen
dc.subjectONE-STEP CONVERSIONen
dc.subjectBIOLOGICALen
dc.subjectEVALUATIONen
dc.subjectN-4-BENZOYL CYTOSINEen
dc.subjectUNSATURATED KETONUCLEOSIDESen
dc.subjectN-6-BENZOYL ADENINEen
dc.subjectVICINAL DIOLSen
dc.subject1,5-ANHYDROHEXITOL NUCLEOSIDESen
dc.subjectEXOCYCLIC METHYLENEen
dc.subjectANTIVIRAL ACTIVITYen
dc.subjectChemistry, Medicinalen
dc.titleKeto and Exomethylene Pyranonucleosides as Antitumor Agentsen
dc.typejournalArticleen


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