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The selective 5-HT6 receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
dc.creator | Pitsikas, N. | en |
dc.creator | Zisopouiou, S. | en |
dc.creator | Pappas, I. | en |
dc.creator | Sakellaridis, N. | en |
dc.date.accessioned | 2015-11-23T10:45:43Z | |
dc.date.available | 2015-11-23T10:45:43Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1016/j.bbr.2007.11.010 | |
dc.identifier.issn | 0166-4328 | |
dc.identifier.uri | http://hdl.handle.net/11615/32314 | |
dc.description.abstract | There are experimental evidences indicating that the non-competitive NMDA receptor antagonist MK-801 impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hypermotility, stereotypies and ataxia). The present study was designed to investigate the efficacy of the selective 5-HT6 receptor antagonist Ro 04-6790 in counteracting these MK-801-induced behavioural effects in the rat. The effects of Ro 04-6790 in antagonizing MK-801-induced memory deficits were assessed using the object recognition task. The ability of this 5-HT6 receptor antagonist in counteracting hypermotility, stereotypies and ataxia produced by MK-801 were evaluated in a motor activity cage. Post-training administration of Ro 04-6790 (10 and to some extent also 3 mg/kg) antagonized MK-801-induced performance deficits in a recognition memory test. In a subsequent study, Ro 04-6790 (3 and 10mg/kg) reversed hypermotility and ataxia produced by MK-801. This 5-HT6 receptor antagonist also alleviated MK-801-induced certain stereotypies. Our findings indicate that Ro 04-6790 attenuates behavioural effects related to the hypofunction of the NMDA receptor suggesting that this compound might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. (C) 2007 Elsevier B.V. All rights reserved. | en |
dc.source | Behavioural Brain Research | en |
dc.source.uri | <Go to ISI>://WOS:000254217700009 | |
dc.subject | MK-801 | en |
dc.subject | Ro 04-6790 | en |
dc.subject | 5-HT6 receptor | en |
dc.subject | motility | en |
dc.subject | stereotypies | en |
dc.subject | ataxia | en |
dc.subject | recognition memory | en |
dc.subject | OBJECT RECOGNITION | en |
dc.subject | SEROTONIN RECEPTOR | en |
dc.subject | PREFRONTAL CORTEX | en |
dc.subject | RAT | en |
dc.subject | SCHIZOPHRENIA | en |
dc.subject | MEMORY | en |
dc.subject | SB-271046 | en |
dc.subject | MODEL | en |
dc.subject | CONSOLIDATION | en |
dc.subject | LOCALIZATION | en |
dc.subject | Behavioral Sciences | en |
dc.subject | Neurosciences | en |
dc.title | The selective 5-HT6 receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801 | en |
dc.type | journalArticle | en |
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