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Matrix Metalloproteinase Levels in the Differentiation of Parapneumonic Pleural Effusions
dc.creator | Oikonomidi, S. | en |
dc.creator | Kostikas, K. | en |
dc.creator | Kalomenidis, I. | en |
dc.creator | Tsilioni, I. | en |
dc.creator | Daenas, C. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Kiropoulos, T. S. | en |
dc.date.accessioned | 2015-11-23T10:41:41Z | |
dc.date.available | 2015-11-23T10:41:41Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1159/000314586 | |
dc.identifier.issn | 0025-7931 | |
dc.identifier.uri | http://hdl.handle.net/11615/31471 | |
dc.description.abstract | Background: Matrix metalloproteinases (MMPs) have been implicated in the escalation of fibrosis and remodeling which are central to the subsequent progression of a parapneumonic pleural effusion to empyema. Objectives: The aim of this study was the assessment of MMP-2, MMP-8 and MMP-9 in parapneumonic pleural effusions in order to examine their value in the differentiation between uncomplicated and complicated parapneumonic effusions. Methods: The study included 208 consecutive patients with pleural effusions [60 parapneumonic (27 uncomplicated parapneumonic, 17 complicated parapneumonic, 16 empyemas), 24 tuberculous, 89 malignant and 35 transudates]. Concentrations of pleural fluid and serum MMP-2, MMP-8 and MMP-9 were determined by immunoassay. Results: Pleural fluid MMP-8 and MMP-9 levels were higher in complicated parapneumonic effusions or empyema than in uncomplicated effusions, while their serum levels were higher in complicated par apneumonic effusions. MMP-2 levels were higher in uncomplicated than in complicated parapneumonic effusions or empyema. Pleural fluid MMP-2/MMP-9 ratio was the best marker to differentiate complicated from uncomplicated parapneumonic effusions, with a sensitivity of 94.1% and a specificity of 77.8% at a cut-off point of 1.32 (AUC = 0.887). Conclusions: Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions. Copyright (C) 2010 S. Karger AG, Basel | en |
dc.source.uri | <Go to ISI>://WOS:000281224000004 | |
dc.subject | Empyema | en |
dc.subject | Fibrosis | en |
dc.subject | Matrix metalloproteinases | en |
dc.subject | Pleural effusion | en |
dc.subject | Pleural | en |
dc.subject | infection | en |
dc.subject | TISSUE INHIBITORS | en |
dc.subject | MESOTHELIAL CELLS | en |
dc.subject | NON-PURULENT | en |
dc.subject | FLUID | en |
dc.subject | EXPRESSION | en |
dc.subject | CANCER | en |
dc.subject | TUBERCULOSIS | en |
dc.subject | EMPYEMA | en |
dc.subject | DISEASE | en |
dc.subject | MARKER | en |
dc.subject | Respiratory System | en |
dc.title | Matrix Metalloproteinase Levels in the Differentiation of Parapneumonic Pleural Effusions | en |
dc.type | journalArticle | en |
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