Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta
dc.creator | Heidrich, B. | en |
dc.creator | Yurdaydin, C. | en |
dc.creator | Kabaçam, G. | en |
dc.creator | Ratsch, B. A. | en |
dc.creator | Zachou, K. | en |
dc.creator | Bremer, B. | en |
dc.creator | Dalekos, G. N. | en |
dc.creator | Erhardt, A. | en |
dc.creator | Tabak, F. | en |
dc.creator | Yalcin, K. | en |
dc.creator | Gürel, S. | en |
dc.creator | Zeuzem, S. | en |
dc.creator | Cornberg, M. | en |
dc.creator | Bock, C. T. | en |
dc.creator | Manns, M. P. | en |
dc.creator | Wedemeyer, H. | en |
dc.date.accessioned | 2015-11-23T10:30:06Z | |
dc.date.available | 2015-11-23T10:30:06Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1002/hep.27102 | |
dc.identifier.issn | 2709139 | |
dc.identifier.uri | http://hdl.handle.net/11615/28490 | |
dc.description.abstract | Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials investigating the efficacy of pegylated interferon alpha (PEG-IFNa) showed HDV RNA negativity rates of 25-30% 24 weeks after therapy. However, the clinical and virological long-term outcome of HDV-infected patients treated with PEG-IFNa is unknown. We performed a retrospective-prospective follow-up of 77 patients treated for 48 weeks with either PEG-alfa-2a and adefovir (ADV) or either drug alone in the Hep-Net-International-Delta-Hepatitis-Intervention-Study 1 (HIDIT-1) trial. Long-term follow-up data were available for 58 out of 77 patients (75%) with a median time of follow-up of 4.5 (0.5-5.5) years and a median 3 visits per patient. Patients treated with ADV alone received retreatment with PEG-IFNa (48% versus 19%; P = 0.02) more often. Hepatitis B virus surface antigen (HBsAg) became negative in six PEG-IFNa-treated patients until the end of long-term follow-up (10%). Sixteen patients tested HDV RNA-negative 6 months after PEG-IFNa treatment who were entered in the long-term follow-up study. Out of these, nine individuals tested HDV RNA-positive at least once during further long-term follow-up, with seven patients being HDV RNA-positive at the most recent visit. Clinical endpoints (liver-related death, liver transplantation, hepatic decompensation, hepatocellular carcinoma) were observed in three PEG-IFNa-treated (8%) and three ADV-treated (14%) patients during posttreatment long-term follow-up with an overall annual event rate of 2.5% (4.9% in cirrhosis). Sequencing confirmed the reappearance of pretreatment virus strains in all cases. Conclusion: Late HDV RNA relapses may occur after PEG-IFNa therapy of hepatitis delta and thus the term sustained virological response should be avoided in HDV infection. The annual posttreatment rate of clinical events in hepatitis delta patients eligible for PEG-IFNa therapy is about 2.5% and 4.9% in patients with cirrhosis. (Hepatology 2014;60:87-97) © 2014 by the American Association for the Study of Liver Diseases. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84902091591&partnerID=40&md5=63df5234fa45bb30d1b3cbd9f687d609 | |
dc.subject | adefovir dipivoxil | en |
dc.subject | hepatitis B surface antigen | en |
dc.subject | peginterferon alpha2a | en |
dc.subject | placebo | en |
dc.subject | virus RNA | en |
dc.subject | adolescent | en |
dc.subject | adult | en |
dc.subject | antiviral therapy | en |
dc.subject | article | en |
dc.subject | clinical trial | en |
dc.subject | controlled study | en |
dc.subject | decompensated liver cirrhosis | en |
dc.subject | delta agent hepatitis | en |
dc.subject | drug efficacy | en |
dc.subject | event free survival | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | hemoperitoneum | en |
dc.subject | Hepatitis delta virus | en |
dc.subject | human | en |
dc.subject | liver | en |
dc.subject | liver cell carcinoma | en |
dc.subject | liver cirrhosis | en |
dc.subject | liver transplantation | en |
dc.subject | long term care | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | priority journal | en |
dc.subject | prospective study | en |
dc.subject | recurrent infection | en |
dc.subject | retrospective study | en |
dc.subject | RNA sequence | en |
dc.subject | treatment duration | en |
dc.subject | upper gastrointestinal bleeding | en |
dc.subject | virus strain | en |
dc.subject | Aged | en |
dc.subject | Antiviral Agents | en |
dc.subject | Disease-Free Survival | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Hepatitis D, Chronic | en |
dc.subject | Humans | en |
dc.subject | Interferon-alpha | en |
dc.subject | Middle Aged | en |
dc.subject | Polyethylene Glycols | en |
dc.subject | Prospective Studies | en |
dc.subject | Recombinant Proteins | en |
dc.subject | Recurrence | en |
dc.subject | Retrospective Studies | en |
dc.subject | RNA, Viral | en |
dc.subject | Treatment Outcome | en |
dc.subject | Young Adult | en |
dc.title | Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta | en |
dc.type | journalArticle | en |
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