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Relationship between vitamin D and muscle size and strength in patients on hemodialysis
dc.creator | Gordon, P. L. | en |
dc.creator | Sakkas, G. K. | en |
dc.creator | Doyle, J. W. | en |
dc.creator | Shubert, T. | en |
dc.creator | Johansen, K. L. | en |
dc.date.accessioned | 2015-11-23T10:28:39Z | |
dc.date.available | 2015-11-23T10:28:39Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1053/j.jrn.2007.06.001 | |
dc.identifier.issn | 1051-2276 | |
dc.identifier.uri | http://hdl.handle.net/11615/28050 | |
dc.description.abstract | Objective: Vitamin D has various actions in skeletal muscle. The purpose of this study was to compare lower-limb muscle size and strength in hemodialysis (HD) patients being treated with 1,25-dihydroxyvitamin D (calcitriol) or a 1,25-dihydroxyvitamin D analogue (paricalcitol) with lower-limb muscle size and strength in HD patients who were receiving none. Design: This was a retrospective, cross-sectional study. Setting: This study was performed in outpatient HD centers. Patients: Hemodialysis patients receiving calcitriol or paricalcitol (active vitamin D) for control of secondary hyperparathyroidism (VitD, n = 49) were compared with HD patients who were not (n = 30). Main Outcome Measures: The main outcome measures included the cross-sectional areas (CSAs) of the thigh and tibialis anterior muscles by magnetic resonance imaging, and three measures of strength: the three-repetition maximum (3RM) for knee extension (isotonic), the peak torque of knee extensors (isokinetic), and maximal voluntary contraction of the ankle dorsiflexor muscles (isometric). Results: There were no differences in age, weight, dialysis vintage, or intact parathyroid hormone levels between groups, although serum albumin was higher in the VitD group (P < .05). Patients in the VitD group had a larger thigh-muscle CSA (P < .05) and were stronger across all strength measures (P < .05) after controlling for age and gender (by analysis of covariance). When all analyses were subsequently adjusted for serum albumin concentration, only the difference in 3RM knee-extension strength lost significance. There were no significant differences in any measurements between patients who received calcitriol or paricalcitol. Conclusion: Treatment with active vitamin D was associated with greater muscle size and strength in this cohort of HD patients. (C) 2007 by the National Kidney Foundation, Inc. | en |
dc.source.uri | <Go to ISI>://WOS:000251146500005 | |
dc.subject | CHRONIC-RENAL-FAILURE | en |
dc.subject | SKELETAL-MUSCLE | en |
dc.subject | 1,25-DIHYDROXYVITAMIN-D LEVELS | en |
dc.subject | CARDIOVASCULAR MORTALITY | en |
dc.subject | D METABOLITES | en |
dc.subject | D-DEFICIENT | en |
dc.subject | DISEASE | en |
dc.subject | RATS | en |
dc.subject | PERFORMANCE | en |
dc.subject | 1,25-DIHYDROXYCHOLECALCIFEROL | en |
dc.subject | Nutrition & Dietetics | en |
dc.subject | Urology & Nephrology | en |
dc.title | Relationship between vitamin D and muscle size and strength in patients on hemodialysis | en |
dc.type | journalArticle | en |
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