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Mitogen-inducible gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer

dc.creatorGkretsi, V.en
dc.creatorPapanikolaou, V.en
dc.creatorZacharia, L. C.en
dc.creatorAthanassiou, E.en
dc.creatorWu, C.en
dc.creatorTsezou, A.en
dc.date.accessioned2015-11-23T10:28:32Z
dc.date.available2015-11-23T10:28:32Z
dc.date.issued2013
dc.identifier.issn2507005
dc.identifier.urihttp://hdl.handle.net/11615/28013
dc.description.abstractBackground: Cell adhesion proteins that connect each cell to neighboring cells and the extracellular matrix play a fundamental role in metastasis. Mitogen-inducible gene-2 (MIG2), is a cell-matrix adhesion protein, which through migfilin, interacts with filamin-A, being linked to actin cytoskeleton. Aim: Recent studies have implicated both MIG2 and migfilin in cancer, but little is known regarding their expression in breast cancer. In this study, we investigated this topic. Materials and Methods: mRNA and protein expression was examined in 30 breast cancer samples and compared to that of normal adjacent tissue using real time-polymerase chain reaction (PCR) and western blotting. Results: Our results showed that expression of MIG2 and migfilin was significantly reduced in the majority of the breast cancer tissues compared to normal tissues regardless of metastatic status and disease stage. Conclusion: Both MIG2 and migfilin are down-regulated in breast cancer.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84878180353&partnerID=40&md5=96991b2682301fb164751c1e3e4f5c93
dc.subjectBreast canceren
dc.subjectMIG2en
dc.subjectMigfilinen
dc.subjectMitogen-inducible gene-2en
dc.subjectmessenger RNAen
dc.subjectmigfilin proteinen
dc.subjectmitogen inducible gene 2en
dc.subjectproteinen
dc.subjectunclassified drugen
dc.subjectarticleen
dc.subjectcancer tissueen
dc.subjectclinical articleen
dc.subjectcomparative studyen
dc.subjectfemaleen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjecthuman tissueen
dc.subjectpriority journalen
dc.subjectprotein expressionen
dc.subjectreal time polymerase chain reactionen
dc.subjectWestern blottingen
dc.subjectBlotting, Westernen
dc.subjectBreasten
dc.subjectBreast Neoplasmsen
dc.subjectCarcinoma, Ductal, Breasten
dc.subjectCarcinoma, Intraductal, Noninfiltratingen
dc.subjectCarcinoma, Lobularen
dc.subjectCell Adhesion Moleculesen
dc.subjectCytoskeletal Proteinsen
dc.subjectHumansen
dc.subjectMembrane Proteinsen
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Proteinsen
dc.subjectPrognosisen
dc.subjectReal-Time Polymerase Chain Reactionen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectRNA, Messengeren
dc.subjectTumor Markers, Biologicalen
dc.titleMitogen-inducible gene-2 (MIG2) and migfilin expression is reduced in samples of human breast canceren
dc.typejournalArticleen


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