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Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study
dc.creator | Giannaki, C. D. | en |
dc.creator | Sakkas, G. K. | en |
dc.creator | Karatzaferi, C. | en |
dc.creator | Hadjigeorgiou, G. M. | en |
dc.creator | Lavdas, E. | en |
dc.creator | Kyriakides, T. | en |
dc.creator | Koutedakis, Y. | en |
dc.creator | Stefanidis, I. | en |
dc.date.accessioned | 2015-11-23T10:27:56Z | |
dc.date.available | 2015-11-23T10:27:56Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1186/1471-2369-14-194 | |
dc.identifier.issn | 1471-2369 | |
dc.identifier.uri | http://hdl.handle.net/11615/27854 | |
dc.description.abstract | Background: Restless Legs Syndrome is very common in hemodialysis patients however there are no comparative studies assessing the effectiveness of a non-pharmacological treatment to a classical treatment on parameters related to syndromes' severity and quality of life. Methods: In this randomized, partially double blind, placebo controlled trial, thirty two hemodialysis patients with restless legs syndrome were randomly assigned into three groups: 1) the exercise training group (N = 16), 2) the dopamine agonists group (ropinirole 0.25 mg/d) (N = 8) and 3) the placebo group (N = 8). The intervention programs lasted 6 months. Restless Legs Syndrome severity was assessed using the international severity scale, physical performance by a battery of tests, muscle size and composition by computed tomography, body composition by Dual Energy X Ray Absorptiometry, while depression score, sleep quality, daily sleepiness and quality of life were assessed through questionnaires. Results: Exercise training and dopamine agonists were effective in reducing syndrome's symptoms by 46% (P = 0.009) and 54% (P = 0.001) respectively. Within group changes revealed that both approaches significantly improved quality of life (P < 0.05), however, only the dopamine agonists significantly improved sleep quality (P = 0.009). Within group changes showed a tendency for lean body mass improvements with dopamine agonists, this reached statistical significance only with the exercise training (P = 0.014), which also reduced fat infiltration in muscles (P = 0.044) and improved physical performance (P > 0.05) in various tests. Between group changes detect significant improvements with both exercise and dopamine agonists in depression score (P = 0.003), while only the dopamine agonist treatment was able to significantly improve sleep quality, compared to exercise and placebo (P = 0.016). Conclusions: A 6-month exercise training regime was as effective as a 6-month low dosage dopamine agonist treatment in reducing restless legs syndrome symptoms and improving depression score in uremic patients. Further research is needed in order to show whether a combination treatment could be more beneficial for the amelioration of RLS. | en |
dc.source.uri | <Go to ISI>://WOS:000324468900002 | |
dc.subject | Extramyocellular lipids | en |
dc.subject | Lean body mass | en |
dc.subject | Muscle atrophy | en |
dc.subject | Quality of | en |
dc.subject | life | en |
dc.subject | Sleep | en |
dc.subject | STAGE RENAL-DISEASE | en |
dc.subject | QUALITY-OF-LIFE | en |
dc.subject | CHRONIC KIDNEY-DISEASE | en |
dc.subject | DIALYSIS | en |
dc.subject | PATIENTS | en |
dc.subject | CONTROLLED-TRIAL | en |
dc.subject | INTRAMYOCELLULAR LIPIDS | en |
dc.subject | FUNCTIONAL-CAPACITY | en |
dc.subject | INSULIN-RESISTANCE | en |
dc.subject | CROSSOVER TRIAL | en |
dc.subject | HEMODIALYSIS | en |
dc.subject | Urology & Nephrology | en |
dc.title | Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: a six-month randomized, partially double-blind, placebo-controlled comparative study | en |
dc.type | journalArticle | en |
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