dc.creator | Dimopoulou, A. | en |
dc.creator | Manta, S. | en |
dc.creator | Parmenopoulou, V. | en |
dc.creator | Gkizis, P. | en |
dc.creator | Coutouli-Argyropoulou, E. | en |
dc.creator | Schols, D. | en |
dc.creator | Komiotis, D. | en |
dc.date.accessioned | 2015-11-23T10:25:44Z | |
dc.date.available | 2015-11-23T10:25:44Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1080/15257770.2014.992532 | |
dc.identifier.issn | 1525-7770 | |
dc.identifier.uri | http://hdl.handle.net/11615/27119 | |
dc.description.abstract | We report the synthesis of novel thiopurine pyranonucleosides. Direct coupling of silylated 6-mercaptopurine and 6-thioguanine with the appropriate pyranoses 1a-e via Vorbruggen nucleosidation, gave the N-9 linked mercaptopurine 2a-e and thioguanine 4a-e nucleosides, while their N-7 substituted congeners 10a-e and 7a-e, were obtained through condensation of the same acetates with 6-chloro and 2-amino-6-chloropurines, followed by subsequent thionation. Nucleosides 3a-e, 5a-e, 8a-e, and 11a-e were evaluated for their cytostatic activity in three different tumor cell proliferative assays. | en |
dc.source | Nucleosides Nucleotides & Nucleic Acids | en |
dc.source.uri | <Go to ISI>://WOS:000350961500005 | |
dc.subject | pyranonucleosides | en |
dc.subject | cytotoxic activity | en |
dc.subject | 6-chloropurine | en |
dc.subject | 6-thioguanine | en |
dc.subject | 2-amino-6-chloropurine | en |
dc.subject | 6-Mercaptopurine | en |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | en |
dc.subject | FLUORO-KETOPYRANOSYL NUCLEOSIDES | en |
dc.subject | ACUTE | en |
dc.subject | LYMPHOBLASTIC-LEUKEMIA | en |
dc.subject | GLYCOGEN-PHOSPHORYLASE B | en |
dc.subject | PYRIMIDINE | en |
dc.subject | PYRANONUCLEOSIDES | en |
dc.subject | N-4-BENZOYL CYTOSINE | en |
dc.subject | UNSATURATED EXOMETHYLENE | en |
dc.subject | BIOLOGICAL EVALUATION | en |
dc.subject | N-6-BENZOYL ADENINE | en |
dc.subject | ANTITUMOR AGENTS | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | Synthesis of Novel Thiopurine Pyranonucleosides: Evaluation of Their Bioactivity | en |
dc.type | journalArticle | en |