| dc.creator | Dimopoulou, A. | en |
| dc.creator | Manta, S. | en |
| dc.creator | Kiritsis, C. | en |
| dc.creator | Gkaragkouni, D. N. | en |
| dc.creator | Papasotiriou, I. | en |
| dc.creator | Balzarini, J. | en |
| dc.creator | Komiotis, D. | en |
| dc.date.accessioned | 2015-11-23T10:25:43Z | |
| dc.date.available | 2015-11-23T10:25:43Z | |
| dc.date.issued | 2013 | |
| dc.identifier | 10.1016/j.bmcl.2012.12.092 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | http://hdl.handle.net/11615/27118 | |
| dc.description.abstract | A microwave-assisted, one-pot, coupling reaction for the synthesis of C5-alkynyl-uracil and cytosine glucopyranonucleosides has been developed. The reaction is carried out under standard Sonogashira coupling conditions from glucopyranonucleosides of 5-iodouracil or 5-iodocytosine and various terminal alkynes. All compounds were evaluated for their cytostatic and antiviral activity. The 5-phenylethynyluracil pyranonucleoside derivative 6a showed the most promising cytostatic activity (50% inhibitory concentration in the lower micromolar range). No meaningful antiviral activity was recorded. (C) 2013 Elsevier Ltd. All rights reserved. | en |
| dc.source.uri | <Go to ISI>://WOS:000314693400035 | |
| dc.subject | C5-Alkynyl pyranonucleosides | en |
| dc.subject | Microwave-irradiation | en |
| dc.subject | Sonogashira | en |
| dc.subject | coupling reaction | en |
| dc.subject | Cytotoxic activity | en |
| dc.subject | NUCLEOSIDE ANALOGS | en |
| dc.subject | THYMIDINE KINASE | en |
| dc.subject | Chemistry, Medicinal | en |
| dc.subject | Chemistry, Organic | en |
| dc.title | Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents | en |
| dc.type | journalArticle | en |