• Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Theodorou E., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2022)
      (1) Background: Considerable inconsistency exists regarding the neural substrates of anosognosia in dementia in previous neuroimaging studies. The purpose of this study was the evaluation of anosognosia perfusion correlates ...
    • Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration 

      Rivard L., Friberg L., Conen D., Healey J.S., Berge T., Boriani G., Brandes A., Calkins H., Camm A.J., Yee Chen L., Lluis Clua Espuny J., Collins R., Connolly S., Dagres N., Elkind M.S.V., Engdahl J., Field T.S., Gersh B.J., Glotzer T.V., Hankey G.J., Harbison J.A., Georg Haeusler K., Hills M.T., Johnson L.S.B., Joung B., Khairy P., Kirchhof P., Krieger D., Lip G.Y.H., Løchen M.-L., Madhavan M., Mairesse G.H., Montaner J., Ntaios G., Quinn T.J., Rienstra M., Rosenqvist M., Sandhu R.K., Smyth B., Schnabel R.B., Stavrakis S., Themistoclakis S., Van Gelder I.C., Wang J.-G., Freedman B. (2022)
      Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration ...
    • Black holes and high levels of neurofilaments in glial fibrillary acidic protein – astrocytopathy: a case report 

      Papa A., Tzartos J.S., Sakoutis G., Dardiotis E., Alexiou E., Breza M., Velonakis G., Papamichalis P., Mpampalis D., Komnos A., Karagiorgou A., Papakonstantinou A., Kilidireas C., Hadjigeorgiou G.M. (2020)
      Background and purpose: Glial fibrillary acidic protein (GFAP) is an intracellular protein of the astrocytic cytoskeleton. Recently, autoantibodies to GFAP detected by cell-based assay in cerebrospinal fluid (CSF) or serum ...
    • Brain MRI and proton MRS findings in infants and children with respiratory chain defects 

      Dinopoulos, A.; Cecil, K. M.; Schapiro, M. B.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Wong, B.; DeGrauw, T.; Egelhoff, J. C. (2005)
      Objective: The aim of this study is to describe neuroimaging patterns in children with respiratory chain (RC) defects using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) and to assess ...
    • CADASIL in Greece: Mutational spectrum and clinical characteristics based on a systematic review and pooled analysis of published cases 

      Paraskevas G.P., Stefanou M.I., Constantinides V.C., Bakola E., Chondrogianni M., Giannopoulos S., Kararizou E., Boufidou F., Zompola C., Tsantzali I., Theodorou A., Palaiodimou L., Vikelis M., Lachanis S., Papathanasiou M., Bakirtzis C., Koutroulou I., Karapanayiotides T., Xiromerisiou G., Kapaki E., Tsivgoulis G. (2022)
      Background: Differences have been noted in the clinical presentation and mutational spectrum of CADASIL among various geographical areas. The aim of the present study was to investigate the mode of clinical presentation ...
    • Cancer-associated stroke: Pathophysiology, detection and management (Review) 

      Dardiotis E., Aloizou A.-M., Markoula S., Siokas V., Tsarouhas K., Tzanakakis G., Libra M., Kyritsis A.P., Brotis A.G., Aschner M., Gozes I., Bogdanos D.P., Spandidos D.A., Mitsias P.D., Tsatsakis A. (2019)
      Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital ...
    • Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine 

      Nijs J., George S.Z., Clauw D.J., Fernández-de-las-Peñas C., Kosek E., Ickmans K., Fernández-Carnero J., Polli A., Kapreli E., Huysmans E., Cuesta-Vargas A.I., Mani R., Lundberg M., Leysen L., Rice D., Sterling M., Curatolo M. (2021)
      Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms ...
    • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy revisited: Genotype-phenotype correlations of all published cases 

      Xiromerisiou G., Marogianni C., Dadouli K., Zompola C., Georgouli D., Provatas A., Theodorou A., Zervas P., Nikolaidou C., Stergiou S., Ntellas P., Sokratous M., Stathis P., Paraskevas G.P., Bonakis A., Voumvourakis K., Hadjichristodoulou C., Hadjigeorgiou G.M., Tsivgoulis G. (2020)
      Objective The aim of this study was to evaluate the correlation between the various NOTCH3 mutations and their clinical and genetic profile, along with the presentation of a novel mutation in a patient.MethodsHere, we ...
    • Clinical outcomes and neuroimaging profiles in nondisabled patients with anticoagulant-related intracerebral hemorrhage 

      Lioutas V.-A., Goyal N., Katsanos A.H., Krogias C., Zand R., Sharma V.K., Varelas P., Malhotra K., Paciaroni M., Sharaf A., Chang J., Karapanayiotides T., Kargiotis O., Pappa A., Mai J., Pandhi A., Schroeder C., Tsantes A., Mehta C., Kerro A., Khan A., Mitsias P.D., Selim M.H., Alexandrov A.V., Tsivgoulis G. (2018)
      Background and Purpose: The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K ...
    • Clinically reliable cognitive decline in relapsing remitting multiple sclerosis: Is it the tip of the iceberg? 

      Andravizou A., Siokas V., Artemiadis A., Bakirtzis C., Aloizou A.-M., Grigoriadis N., Kosmidis M.H., Nasios G., Messinis L., Hadjigeorgiou G., Dardiotis E., Peristeri E. (2020)
      Objectives: Cognitive impairment is common in multiple sclerosis, but the brain MRI correlates in relapsing remitting multiple sclerosis remain controversial. The current study aimed to investigate whether cognitive decline ...
    • Clinically silent small vessel disease of the brain in patients with obstructive sleep apnea hypopnea syndrome 

      Raptis D.G., Sinani O., Rapti G.G., Papanikolaou A., Dadouli K., Ntellas P., Kapsalaki E.Z., Malli F., Gourgoulianis K.I., Xiromerisiou G. (2021)
      Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with increased risk of cerebrovascular disease. The aim of the present study was to investigate the association between the presence of the small vessel disease ...
    • Cognitive deficits in myopathies 

      Peristeri E., Aloizou A.-M., Keramida P., Tsouris Z., Siokas V., Mentis A.-F.A., Dardiotis E. (2020)
      Myopathies represent a wide spectrum of heterogeneous diseases mainly characterized by the abnormal structure or functioning of skeletal muscle. The current paper provides a comprehensive overview of cognitive deficits ...
    • Common and Uncommon Artifacts in T1 FLAIR SAG Sequences of MRI Brain 

      Lavdas E., Papaioannou M., Boci N., Dardiotis E., Roka V., Sakkas G.K., Apostolopoulou G., Gogou L., Mavroidis P. (2021)
      Objective: This study aims at identifying, classifying, and measuring the frequency the different artifacts that show up in the images of the Sagittal T1 Fluid Attenuated Inversion Recovery (FLAIR) sequence. Materials and ...
    • Confidence intervals for differences between volumes under receiver operating characteristic surfaces (VUS) and generalized Youden indices (GYIs) 

      Yin J., Nakas C.T., Tian L., Reiser B. (2018)
      This article explores both existing and new methods for the construction of confidence intervals for differences of indices of diagnostic accuracy of competing pairs of biomarkers in three-class classification problems and ...
    • Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays 

      Tzartos J.S., Karagiorgou K., Tzanetakos D., Breza M., Evangelopoulos M.E., Pelidou S.-H., Bakirtzis C., Nikolaidis I., Koutsis G., Notas K., Chroni E., Markakis I., Grigoriadis N.C., Anagnostouli M., Orologas A., Parisis D., Karapanayiotides T., Papadimitriou D., Kostadima V., Elloul J., Xidakis I., Maris T., Zisimopoulou P., Tzartos S., Kilidireas C. (2020)
      IgG antibodies to myelin oligodendrocyte glycoprotein (MOG) detected by cell based assays (CBA) have been identified in a constantly expanding spectrum of CNS demyelinating disorders. However, a universally accepted CBA ...
    • Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage 

      Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)
      Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ...
    • Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial 

      Fischer U., Trelle S., Branca M., Salanti G., Paciaroni M., Ferrari C., Abend S., Beyeler S., Strbian D., Thomalla G., Ntaios G., Bonati L.H., Michel P., Nedeltchev K., Gattringer T., Sandset E.C., Kelly P., Lemmens R., Koga M., Sylaja P.N., de Sousa D.A., Bornstein N.M., Gdovinova Z., Seiffge D.J., Gralla J., Horvath T., Dawson J. (2022)
      Rationale: Direct oral anticoagulants (DOAC) are highly effective in preventing ischaemic strokes in people with atrial fibrillation (AF). However, it is unclear how soon they should be started after acute ischaemic stroke ...
    • Eating Disorders in Frontotemporal Dementia and Alzheimer's Disease: Evaluation of Brain Perfusion Correlates Using 99mTc-HMPAO SPECT with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Eating disorders (ED) in dementia represent a significant impairment affecting patients' and caregivers' lives. In frontotemporal dementia (FTD), ED include overeating, sweet food preference, stereotypical ...
    • Endovascular Thrombectomy in Acute Ischemic Stroke 

      Papanagiotou P., Ntaios G. (2018)
      Despite several effective strategies of stroke prevention, the stroke epidemic still constitutes the leading cause of permanent disability. The recent series of well-designed, convincingly-positive randomized controlled ...
    • Exploiting morphology and texture of 3D tumor models in DTI for differentiating glioblastoma multiforme from solitary metastasis 

      Vamvakas A., Tsougos I., Arikidis N., Kapsalaki E., Fountas K., Fezoulidis I., Costaridou L. (2018)
      Ambiguous imaging appearance of Glioblastoma Multiforme (GBM) and solitary Metastasis (MET) is a challenge to conventional Magnetic Resonance Imaging (MRI) based diagnosis, leading to exploitation of advanced MRI techniques, ...