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    • Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis 

      Tsezou, A.; Karachalios, T.; Fytili, P.; Giannatou, E.; Christodoulou, K.; Hadjigeorgiou, G. M.; Malizos, K. N. (2006)
      Osteoarthritis (OA) is a common age-related debilitating disease of the joints characterized by degeneration of the articular cartilage which leads to joint pain, discomfort, and immobility. Several risk factors have been ...

    • Genomic Convergence of Genome-wide Investigations for Complex Traits 

      Kitsios, G. D.; Zintzaras, E. (2009)
      Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ...

    • Heterogeneity testing in meta-analysis of genome searches 

      Zintzaras, E.; Ioannidis, J. P. A. (2005)
      Genome searches for identifying susceptibility loci for the same complex disease often give inconclusive or inconsistent results. Genome Search Meta-analysis (GSMA) is an established non-parametric method to identify genetic ...

    • A heterogeneity-based genome search meta-analysis for autism-spectrum disorders 

      Trikalinos, T. A.; Karvouni, A.; Zintzaras, E.; Ylisaukko-oja, T.; Peltonen, L.; Jarvela, I.; Ioannidis, J. P. A. (2006)
      Autism and autism-spectrum disorders exhibit high heritability, although specific susceptibility genes still remain largely elusive. We performed a heterogeneity-based genome search meta-analysis (HEGESMA) of nine genome ...

    • Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass 

      Ioannidis, J. P. A.; Ng, M. Y.; Sham, P. C.; Zintzaras, E.; Lewis, C. M.; Deng, H. W.; Econs, M. J.; Karasik, D.; Devoto, M.; Kammerer, C. M.; Spector, T.; Andrew, T.; Cupples, L. A.; Duncan, E. L.; Foroud, T.; Kiel, D. P.; Koller, D.; Langdahl, B.; Mitchell, B. D.; Peacock, M.; Recker, R.; Shen, H.; Sol-Church, K.; Spotila, L. D.; Uitterlinden, A. G.; Wilson, S. G.; Kung, A. W. C.; Ralston, S. H. (2007)
      Introduction: BMD is a heritable trait and an important predictor of osteoporotic fracture risk. Several genome-wide scans have been performed in an attempt to detect loci that regulate BMD, but there has been limited ...

    • A Multipoint Method for Meta-Analysis of Genetic Association Studies 

      Bagos, P. G.; Liakopoulos, T. D. (2010)
      Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ...