• ACOS syndrome: Single disease entity or not? Could exhaled nitric oxide be a useful biomarker for the differentiation of ACOS, asthma and COPD? 

      Karampitsakos T., Gourgoulianis K.I. (2016)
      Asthma and chronic obstructive pulmonary disease (COPD) represent two major public health problems. However, there is a significant proportion of patients with a mixed asthma-COPD phenotype. This condition is defined as ...
    • C-reactive protein as a potential biomarker of residual obstructive sleep apnea following adenotonsillectomy in children 

      Bhattacharjee R., Kheirandish-Gozal L., Kaditis A.G., Verhulst S.L., Gozal D. (2016)
      Study Objectives: Adenotonsillectomy (AT) is first-line treatment for pediatric obstructive sleep apnea (OSA), with most children having improvements in polysomnography (PSG). However, many children have residual OSA ...
    • Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? 

      Zintzaras, E.; Stefanidis, I.; Santos, M.; Vidal, F. (2006)
      Case-control studies that have investigated the association between alcoholism and alcohol-induced liver damage and the ADH2, ADH3, CYP2E1, and ADLH2 polymorphisms have reported controversial or inconclusive results. Thus, ...
    • The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis 

      Oikonomou E.K., Repanas T.I., Papanastasiou C., Kokkinidis D.G., Miligkos M., Feher A., Gupta D., Kampaktsis P.N. (2016)
      Background In-hospital acquired thrombocytopenia (TP) is relatively common among patients hospitalized with acute coronary syndromes (ACS). However, its effect on short-term and long-term outcomes has yet to be reviewed ...
    • Egg Consumption, Cardiovascular Disease and Cardiometabolic Risk Factors: The Interaction with Saturated Fatty Acids. Results from the ATTICA Cohort Study (2002–2012) 

      Kouvari M., Damigou E., Florentin M., Kosti R.I., Chrysohoou C., Pitsavos C.S., Panagiotakos D.B. (2022)
      Purpose: To examine the association of egg intake with 10-year risk of cardiovascular disease (CVD) and other cardiometabolic risk factors in a sample of individuals of Mediterranean origin. Methods: In 2001–2002, n = 1514 ...
    • Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study 

      Wang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M. (2017)
      A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 ...
    • Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia 

      Hackinger S., Prins B., Mamakou V., Zengini E., Marouli E., Brčić L., Serafetinidis I., Lamnissou K., Kontaxakis V., Dedoussis G., Gonidakis F., Thanopoulou A., Tentolouris N., Tsezou A., Zeggini E. (2018)
      The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ...
    • Examining the stability of genetic risk effect as evidence accumulates in the context of meta-analysis 

      Zintzaras, E. (2013)
      The recursive cumulative meta-analysis (RCM) of genetic association studies explores the relative change of the cumulative risk effect (e.g. OR) in time, indicating the stability of risk effect as evidence accumulates. ...
    • Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: A case control study 

      Pavlidou E., Daponte A., Egea R., Dardiotis E., Hadjigeorgiou G.M., Barbadilla A., Agorastos T. (2016)
      Background: The aim of the study was to evaluate the association of two SNPs of EVER1/2 genes' region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer ...
    • Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) 

      Sacco S., Merki-Feld G.S., Ægidius K.L., Bitzer J., Canonico M., Kurth T., Lampl C., Lidegaard Ø., Anne MacGregor E., MaassenVanDenBrink A., Mitsikostas D.-D., Nappi R.E., Ntaios G., Sandset P.M., Martelletti P., on behalf of the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) (2017)
      Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is ...
    • In-stent graft helical flow intensity reduces the risk of migration after endovascular aortic repair 

      Tasso P., Lodi Rizzini M., Raptis A., Matsagkas M., De Nisco G., Gallo D., Xenos M., Morbiducci U. (2019)
      During the last years endovascular aneurysm repair (EVAR) became the elective treatment for abdominal aortic aneurysms (AAAs) thanks to lower mortality and morbidity rates than open surgery. In face of these advantages, ...
    • Large-scale assessment of polyglutamine repeat expansions in Parkinson disease 

      Wang L., Aasly J.O., Annesi G., Bardien S., Bozi M., Brice A., Carr J., Chung S.J., Clarke C., Crosiers D., Deutschländer A., Eckstein G., Farrer M.J., Goldwurm S., Garraux G., Hadjigeorgiou G.M., Hicks A.A., Hattori N., Klein C., Jeon B., Kim Y.J., Lesage S., Lin J.-J., Lynch T., Lichtner P., Lang A.E., Mok V., Jasinska-Myga B., Mellick G.D., Morrison K.E., Opala G., PihlstrØm L., Pramstaller P.P., Park S.S., Quattrone A., Rogaeva E., Ross O.A., Stefanis L., Stockton J.D., Silburn P.A., Theuns J., Tan E.K., Tomiyama H., Toft M., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Yueh K.-C., Zhao Y., Gasser T., Maraganore D.M., Krüger R., Sharma M. (2015)
      Objectives: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). Methods: We invited researchers from the Genetic ...
    • Lives versus Livelihoods? Perceived economic risk has a stronger association with support for COVID-19 preventive measures than perceived health risk 

      Nisa C.F., Bélanger J.J., Faller D.G., Buttrick N.R., Mierau J.O., Austin M.M.K., Schumpe B.M., Sasin E.M., Agostini M., Gützkow B., Kreienkamp J., Abakoumkin G., Abdul Khaiyom J.H., Ahmedi V., Akkas H., Almenara C.A., Atta M., Bagci S.C., Basel S., Kida E.B., Bernardo A.B.I., Chobthamkit P., Choi H.-S., Cristea M., Csaba S., Damnjanović K., Danyliuk I., Dash A., Di Santo D., Douglas K.M., Enea V., Fitzsimons G., Gheorghiu A., Gómez Á., Grzymala-Moszczynska J., Hamaidia A., Han Q., Helmy M., Hudiyana J., Jeronimus B.F., Jiang D.-Y., Jovanović V., Kamenov Ž., Kende A., Keng S.-L., Kieu T.T.T., Koc Y., Kovyazina K., Kozytska I., Krause J., Kruglanski A.W., Kurapov A., Kutlaca M., Lantos N.A., Lemay E.P., Jr., Lesmana C.B.J., Louis W.R., Lueders A., Malik N.I., Martinez A., McCabe K.O., Mehulić J., Milla M.N., Mohammed I., Molinario E., Moyano M., Muhammad H., Mula S., Muluk H., Myroniuk S., Najafi R., Nyúl B., O’Keefe P.A., Osuna J.J.O., Osin E.N., Park J., Pica G., Pierro A., Rees J., Reitsema A.M., Resta E., Rullo M., Ryan M.K., Samekin A., Santtila P., Selim H.A., Stanton M.V., Sultana S., Sutton R.M., Tseliou E., Utsugi A., van Breen J.A., Van Lissa C.J., Van Veen K., vanDellen M.R., Vázquez A., Wollast R., Yeung V.W.-L., Zand S., Žeželj I.L., Zheng B., Zick A., Zúñiga C., Leander N.P. (2021)
      This paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative ...
    • Nonvitamin-K-antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: An updated systematic review and meta-analysis of randomized controlled trials 

      Ntaios G., Papavasileiou V., Diener H.-C., Makaritsis K., Michel P. (2017)
      Background: In a previous systematic review and meta-analysis, we assessed the efficacy and safety of nonvitamin-K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and stroke or transient ...
    • PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy 

      Papatheodoridis G., Dalekos G., Sypsa V., Yurdaydin C., Buti M., Goulis J., Calleja J.L., Chi H., Manolakopoulos S., Mangia G., Gatselis N., Keskin O., Savvidou S., De La Revilla J., Hansen B.E., Vlachogiannakos I., Galanis K., Idilman R., Colombo M., Esteban R., Janssen H.L.A., Lampertico P. (2016)
      Background & Aims Risk scores for hepatocellular carcinoma (HCC) developed in Asians offer poor-moderate predictability in Caucasian patients with chronic hepatitis B (CHB). This nine center cohort study aimed to develop ...
    • The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants 

      Heckman, M. G.; Elbaz, A.; Soto-Ortolaza, A. I.; Serie, D. J.; Aasly, J. O.; Annesi, G.; Auburger, G.; Bacon, J. A.; Boczarska-Jedynak, M.; Bozi, M.; Brighina, L.; Chartier-Harlin, M. C.; Dardiotis, E.; Destée, A.; Ferrarese, C.; Ferraris, A.; Fiske, B.; Gispert, S.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Klein, C.; Kruger, R.; Kyratzi, E.; Lin, C. H.; Lohmann, K.; Loriot, M. A.; Lynch, T.; Mellick, G. D.; Mutez, E.; Opala, G.; Park, S. S.; Petrucci, S.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Sohn, Y. H.; Stefanis, L.; Tadic, V.; Tomiyama, H.; Uitti, R. J.; Valente, E. M.; Vassilatis, D. K.; Vilariño-Güell, C.; White, L. R.; Wirdefeldt, K.; Wszolek, Z. K.; Wu, R. M.; Xiromerisiou, G.; Maraganore, D. M.; Farrer, M. J.; Ross, O. A. (2014)
      The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the ...
    • A qualitative analysis of Greek innovation activities 

      Halkos, G.; Kitsos, C. (2011)
      This paper analyses the framework, the obstacles, the determinant factors and furthermore the role of female in the Greek entrepreneurship. Apart of presenting the empirical results relying on the analysis of the data ...
    • Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis 

      Ferreiro-Iglesias A., Montes A., Perez-Pampin E., Cañete J.D., Raya E., Magro-Checa C., Vasilopoulos Y., Sarafidou T., Caliz R., Ferrer M.A., Joven B., Carreira P., Balsa A., Pascual-Salcedo D., Blanco F.J., Moreno-Ramos M.J., Fernández-Nebro A., Ordóñez M.C., Alegre-Sancho J.J., Narváez J., Navarro-Sarabia F., Moreira V., Valor L., García-Portales R., Marquez A., Martin J., Gómez-Reino J.J., Gonzalez A. (2016)
      Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have ...
    • The risk of lymphoma development in autoimmune diseases: A meta-analysis 

      Zintzaras, E.; Voulgarelis, M.; Moutsopoulos, H. M. (2005)
      Background: The risk of development of non-Hodgkin lymphoma (NHL) in autoimmune patients has been investigated in several cohort studies. These studies revealed inconclusive results. To shed some light on this controversy, ...
    • Risks in surrogacy considering the embryo: From the preimplantation to the gestational and neonatal period 

      Simopoulou M., Sfakianoudis K., Tsioulou P., Rapani A., Anifandis G., Pantou A., Bolaris S., Bakas P., Deligeoroglou E., Pantos K., Koutsilieris M. (2018)
      Surrogacy is an assisted reproduction-based approach in which the intended parents assign the gestation and birth to another woman called the surrogate mother. The drivers of surrogacy refer largely to infertility, medical ...