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Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations
(2016)Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ... -
Anti-apoptotic and antioxidant activities of the mitochondrial estrogen receptor beta in n2a neuroblastoma cells
(2021)Estrogens are steroid hormones that play a crucial role in the regulation of the reproductive and non-reproductive system physiology. Among non-reproductive systems, the nervous system is mainly affected by estrogens due ... -
Assessing the effect of human factors in healthcare cyber security practice: An empirical study
(2021)In last decades, neuromorphic circuits have received widespread attention across various scientific fields. Such circuits mathematically model the behaviour of biological neurons, synapses as well as their interaction. ... -
Commercially available sensor-based monitoring and support systems in parkinson's disease: An overview
(2021)Parkinson's disease is a progressive neurodegenerative disorder correlating with dysfunction or deprivation of brains dopaminergic neurons, lack of dopamine, and the formation of abnormal protein particles. There are several ... -
Enhanced Ca2+ Entry Sustains the Activation of Akt in Glucose Deprived SH-SY5Y Cells
(2022)The two crucial cellular insults that take place during cerebral ischemia are the loss of oxygen and loss of glucose, which can both activate a cascade of events leading to neuronal death. In addition, the toxic overactivation ... -
Exaggerated haemodynamic and neural responses to involuntary contractions induced by whole-body vibration in normotensive obese versus lean women
(2016)New Findings: What is the central question of this study? In obesity, the exaggerated blood pressure response to voluntary exercise is linked to hypertension, yet the mechanisms are not fully elucidated. We examined whether ... -
Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants
(2018)Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease of the central nervous system, characterized by progressive loss of motor neurons, and occurring in both sporadic and familial form. The origin of ... -
A High-Performance Neuron for Artificial Neural Network based on Izhikevich model
(2019)Neuromorphic circuits have gained a lot of interest through the last decades since they may be deployed in a large spectrum of scientific research. In this paper a hardware realization of a single neuron targeting Field ... -
A low-complexity bit-efficient Neuromorphic Astrocyte-Neuron Circuit
(2021)Experimental and computational evidence accumulated over the last few decades suggests that astrocytes should be requisite and active constituents in neuronal information processing by providing appropriate feedback control ... -
Mitochondrial dynamics and proteins related to neurodegenerative diseases
(2018)Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, ... -
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi – hit, outside – in hypothesis of its pathogenesis
(2020)Following Braak's hypothesis on the infectious pathogenesis of sporadic Parkinson's disease (sPD), several bacteria and viruses have been investigated as likely culprits. Recent research has focused on neuroinvasive influenza ... -
Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP
(2017)Aβ peptide that accumulates in Alzheimer's disease brain, derives from proteolytic processing of the amyloid precursor protein (APP) that exists in three main isoforms derived by alternative splicing. The isoform APP695, ... -
Neurotoxic effects of aluminum are associated with its interference with estrogen receptors signaling
(2020)Aluminum compounds have been observed in various brain regions, and their accumulation has been associated with many neurodegenerative disorders. Neurotoxic effects of aluminum are attributed to reactive oxygen species ... -
On the action of the anti-absence drug ethosuximide in the rat and cat thalamus
(1998)The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In ... -
Parkinson's disease and pesticides: Are microRNAs the missing link?
(2020)Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, ... -
Self-organizing Maps for Optimized Robotic Trajectory Planning Applied to Surface Coating
(2021)The process of surface coating is widely applied in the manufacturing industry. The accuracy of coating strongly affects the mechanical properties of the coated components. This work suggests the use of Self-Organizing ...