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Browsing by Subject "urokinase receptor"

Now showing items 1-11 of 11

    • Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID-19 

      Pan M., Vasbinder A., Anderson E., Catalan T., Shadid H.R., Berlin H., Padalia K., O’hayer P., Meloche C., Azam T.U., Khaleel I., Michaud E., Blakely P., Bitar A., Huang Y., Zhao L., Pop-Busui R., Loosen S.H., Chalkias A., Tacke F., Giamarellos-Bourboulis E.J., Reiser J., Eugen-Olsen J., Hayek S.S. (2021)
      BACKGROUND: Use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID-19 through modulating levels of angiotensin-converting enzyme 2, the cell entry receptor ...

    • Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery 

      Chalkias A., Papagiannakis N., Saugel B., Flick M., Kolonia K., Angelopoulou Z., Ragias D., Papaspyrou D., Bouzia A., Ntalarizou N., Stamoulis K., Kyriakaki A., Eugen-Olsen J., Laou E., Arnaoutoglou E. (2022)
      It remains unknown whether chronic systemic inflammation is associated with impaired microvascular perfusion during surgery. We evaluated the association between the preoperative basal inflammatory state, measured by plasma ...

    • Circulating suPAR associates with severity and in-hospital progression of COVID-19 

      Chalkias A., Skoulakis A., Papagiannakis N., Laou E., Tourlakopoulos K., Pagonis A., Michou A., Ntalarizou N., Mermiri M., Ragias D., Bernal-Morell E., Cebreiros López I., García de Guadiana-Romualdo L., Eugen-Olsen J., Gourgoulianis K., Pantazopoulos I., Chalkias A., Skoulakis A., Laou E., Michou A., Ntalarizou N., Mermiri M., Ragias D., Tourlakopoulos K., Pagonis A., Gourgoulianis K., Pantazopoulos I., Papagiannakis N., Kampolis C., García de Guadiana-Romualdo L., Albaladejo-Otón M.D., Rodríguez Mulero M.D., Galindo Martínez M., Hernández Olivo M., Campos Rodríguez V., Cebreiros López I., Arnaldos Carrillo M., Noguera Velasco J.A., Pascual Figal D.A., Bernal-Morell E., Alcaraz García A., Alcaraz García M.J., Martínez Martínez M., Esteban-Torrella P., Sancho-Rodríguez N., Eugen-Olsen J., for the SPARCOL Investigators (2022)
      Background: COVID-19 disease progression is characterized by hyperinflammation and risk stratification may aid in early aggressive treatment and advanced planning. The aim of this study was to assess whether suPAR and other ...

    • Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature 

      Akinosoglou K., Kapsokosta G., Mouktaroudi M., Rovina N., Kaldis V., Stefos A., Kontogiorgi M., Giamarellos-Bourboulis E., Gogos C., Hellenic Sepsis Study Group (2021)
      Aims: We sought to determine whether primary outcomes differ between non-ICU septic patients with and without type 2 diabetes (T2D). Methods: This study utilized the Hellenic Sepsis Study Group Registry, collecting nationwide ...

    • Elevated preoperative suPAR is a strong and independent risk marker for postoperative complications in patients undergoing major noncardiac surgery (SPARSE) 

      Chalkias A., Laou E., Kolonia K., Ragias D., Angelopoulou Z., Mitsiouli E., Kallemose T., Smith-Hansen L., Eugen-Olsen J., Arnaoutoglou E. (2022)
      Background: Patients undergoing major surgery are often at risk of developing postoperative complications. We investigated whether a preoperative marker of chronic inflammation, soluble urokinase plasminogen activator ...

    • Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19 

      Vasbinder A., Anderson E., Shadid H., Berlin H., Pan M., Azam T.U., Khaleel I., Padalia K., Meloche C., O’hayer P., Michaud E., Catalan T., Feroze R., Blakely P., Launius C., Huang Y., Zhao L., Ang L., Mikhael M., Mizokami-Stout K., Pennathur S., Kretzler M., Loosen S.H., Chalkias A., Tacke F., Giamarellos-Bourboulis E.J., Reiser J., Eugen-Olsen J., Feldman E.L., Pop-Busui R., Hayek S.S. (2022)
      OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) for reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in ...

    • Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group 

      Velissaris D., Dimopoulos G., Parissis J., Alexiou Z., Antonakos N., Babalis D., Gerakari S., Kaldis V., Koutoukas P., Lada M., Leventogiannis K., Pantazopoulos I., Papadopoulos A., Polyzogopoulou E., Gogos C., Armaganidis A., Giamarellos-Bourboulis E.J. (2020)
      In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal ...

    • Serum Levels of Urokinase Plasminogen Activator Receptor (suPAR) Discriminate Moderate Uncontrolled from Severe Asthma 

      Kotsiou O.S., Pantazopoulos I., Mavrovounis G., Marsitopoulos K., Tourlakopoulos K., Kirgou P., Daniil Z., Gourgoulianis K.I. (2022)
      Introduction: The most clinically useful concept in asthma is based on the intensity of treatment required to achieve good asthma control. Biomarkers to guide therapy are needed. Aims: To investigate the role of circulating ...

    • Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID-19 

      Luo S., Vasbinder A., Du-Fay-de-lavallaz J.M., Gomez J.M.D., Suboc T., Anderson E., Tekumulla A., Shadid H., Berlin H., Pan M., Azam T.U., Khaleel I., Padalia K., Meloche C., O’hayer P., Catalan T., Blakely P., Launius C., Amadi K.-M., Pop-Busui R., Loosen S.H., Chalkias A., Tacke F., Giamarellos-Bourboulis E.J., Altintas I., Eugen-Olsen J., Williams K.A., Volgman A.S., Reiser J., Hayek S.S., on behalf of the ISIC (International Study of Inflammation in COVID-19) Group (2022)
      BACKGROUND: Venous thromboembolism (VTE) contributes significantly to COVID-19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels of soluble urokinase plasminogen ...

    • Soluble Urokinase Plasminogen Activator Receptor: A Biomarker for Predicting Complications and Critical Care Admission of COVID-19 Patients 

      Chalkias A., Mouzarou A., Samara E., Xanthos T., Ischaki E., Pantazopoulos I. (2020)
      The novel coronavirus infection has spread worldwide, causing a wide spectrum of clinical manifestations. Most patients develop moderate clinical illness, but a substantial number will experience severe pneumonia, which ...

    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...