Browsing by Subject "urate"
Now showing items 1-4 of 4
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Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials
(2022)Objective: The aim of the present systematic review was to assess the efficacy of ketogenic therapy in Parkinson's disease (PD), using all available data from randomized controlled trials (RCTs) on humans and animal studies ... -
Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation
(2017)Uric acid is a known danger associated molecular pattern molecule able to induce inflammation following internalization of its crystals by cells of the innate immune system. By activating antigen-presenting cells, urate ... -
Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation
(2020)Urate in its crystal form is a known danger-associated molecular pattern, which after its internalization activates cells of the innate immune system. However, by inducing lipid raft sequestration and clustering of ... -
Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes
(2013)Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1β (IL-1β). Purinergic receptor P2X7 ...