Πλοήγηση ανά Θέμα "systemic lupus erythematosus"

2020 international consensus on ANCA testing beyond systemic vasculitis

Moiseev S., Cohen Tervaert J.W., Arimura Y., Bogdanos D.P., Csernok E., Damoiseaux J., Ferrante M., Flores-Suárez L.F., Fritzler M.J., Invernizzi P., Jayne D., Jennette J.C., Little M.A., McAdoo S.P., Novikov P., Pusey C.D., Radice A., Salama A.D., Savige J.A., Segelmark M., Shoenfeld Y., Sinico R.A., Sousa M.-J., Specks U., Terrier B., Tzioufas A.G., Vermeire S., Zhao M.-H., Bossuyt X. (2020)

This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ...

Anti-cd20 agents for multiple sclerosis: Spotlight on ocrelizumab and ofatumumab

Florou D., Katsara M., Feehan J., Dardiotis E., Apostolopoulos V. (2020)

Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a T-cell-mediated disorder. However, newer evidence shows that B ...

Anti-Ro52 antibody is highly prevalent and a marker of better prognosis in patients with ovarian cancer

Bogdanos D.P., Gkoutzourelas A., Papadopoulos V., Liaskos C., Patrikiou E., Tsigalou C., Saratziotis A., Hajiioannou J., Scheper T., Meyer W., Sakkas L.I., Papandreou C. (2021)

Background and Aims: Anti-Ro52 antibody (Ab) reactivity is highly prevalent in autoimmune rheumatic diseases (ARDs), mainly Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE), but also in other inflammatory ...

The autoimmunity–oral microbiome connection

Nikitakis N.G., Papaioannou W., Sakkas L.I., Kousvelari E. (2017)

To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the ...

BAFF receptor polymorphisms and deficiency in humans

Sevdali E., Block Saldana V., Speletas M., Eibel H. (2021)

The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including ...

Clinical and financial burden of active lupus in Greece: A nationwide study

Bertsias G., Karampli E., Sidiropoulos P., Gergianaki I., Drosos A., Sakkas L., Garyfallos A., Tzioufas A., Vassilopoulos D., Tsalapaki C., Sfikakis P., Panopoulos S., Athanasakis K., Perna A., Psomali D., Kyriopoulos J., Boumpas D.T. (2016)

Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients ...

COVID-19 immunopathology and the central nervous system: Implication for multiple sclerosis and other autoimmune diseases with associated demyelination

Boziki M.K., Mentis A.-F.A., Shumilina M., Makshakov G., Evdoshenko E., Grigoriadis N. (2020)

In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and ...

Deciphering the role of DNA methylation in multiple sclerosis: emerging issues

Sokratous M., Dardiotis E., Tsouris Z., Bellou E., Michalopoulou A., Siokas V., Arseniou S., Stamati T., Tsivgoulis G., Bogdanos D., Hadjigeorgiou G.M. (2016)

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence ...

Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults

Ntaios G., Omran S.S. (2022)

[No abstract available]

Enterococcus gallinarum as a component of the Autoinfectome: The gut-liverautoimmune rheumatic disease axis is alive and kicking

Bogdanos D.P., Sakkas L.I. (2018)

[No abstract available]

From microbiome to infectome in autoimmunity

Bogdanos D.P., Sakkas L.I. (2017)

Purpose of review The current review discusses the pros and cons of the microbiome studies conducted in search of the association between microbiota and autoimmunity. Recent findings We focus on the role of infectome and ...

Hair dyes as a risk for autoimmunity: From systemic lupus erythematosus to primary biliary cirrhosis

Smyk, D.; Rigopoulou, E. I.; Bizzaro, N.; Bogdanos, D. P. (2013)

Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized ...

IL-33/ST2 axis in organ fibrosis

Kotsiou O.S., Gourgoulianis K.I., Zarogiannis S.G. (2018)

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by ...

IL-35: a new immunomodulator in autoimmune rheumatic diseases

Sakkas L.I., Mavropoulos A., Perricone C., Bogdanos D.P. (2018)

IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and ...

Infections as a cause of autoimmune rheumatic diseases

Sakkas L.I., Bogdanos D.P. (2016)

Exogenous and endogenous environmental exposures and particularly infections may participate in the breakage of tolerance and the induction of autoimmunity in rheumatic diseases. Response to infections apparently occurs ...

Interstitial lung disease in anti-synthetase syndrome

Kourkouni E., Mitsogiannis G., Simopoulou T., Liaskos C., Katsiari C.G., Daniil Z., Gourgoulianis K., Bogdanos D.P., Sakkas L.I. (2019)

Anti-synthetase syndrome is an autoimmune disorder characterized by the presence of autoantibodies against aminoacyl transfer RNA (tRNA) synthetases, and myositis, interstitial lung disease (ILD), arthritis, fever and ...

Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment

Ceccarelli F., Perricone C., Cipriano E., Massaro L., Natalucci F., Capalbo G., Leccese I., Bogdanos D., Spinelli F.R., Alessandri C., Valesini G., Conti F. (2017)

Objective In the present review, the different phenotypes, clinimetric and imaging tools able to assess joint involvement in patients affected by Systemic Lupus Erythematosus (SLE) have been described and summarized. ...

Mediterranean Journal of Rheumatology September 2019 issue highlights

Sakkas L.I. (2019)

[No abstract available]

Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: An in silico analysis

Vavougios G.D., Zarogiannis S.G., Krogfelt K.A., Gourgoulianis K., Mitsikostas D.D., Hadjigeorgiou G. (2018)

Background currently only 4 studies have explored the potential role of PARK7's dysregulation in MS pathophysiology Currently, no study has evaluated the potential role of the PARK7 interactome in MS. Objective The aim of ...

On the Role of Salt in Immunoregulation and Autoimmunity

Mavropoulos A. (2021)

[No abstract available]