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Πλοήγηση ανά Θέμα "stem cell"

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    • Alterations of microRNAs in solid cancers and their prognostic value 

      Chira, P.; Vareli, K.; Sainis, I.; Papandreou, C.; Briasoulis, E. (2010)
      MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Each miRNA represses the ...

    • Bone marrow side population cells are enriched for progenitors capable of myogenic differentiation 

      Luth, E. S.; Jun, S. J.; Wessen, M. K.; Liadaki, K.; Gussoni, E.; Kunkel, L. M. (2008)
      Although the contribution of bone marrow-derived cells to regenerating skeletal muscle has been repeatedly documented, there remains considerable debate as to whether this incorporation is exclusively a result of inflammatory ...

    • Flash proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response 

      Velalopoulou A., Karagounis I.V., Cramer G.M., Kim M.M., Skoufos G., Goia D., Hagan S., Verginadis I.I., Shoniyozov K., Chiango J., Cerullo M., Varner K., Yao L., Qin L., Hatzigeorgiou A.G., Minn A.J., Putt M., Lanza M., Assenmacher C.-A., Radaelli E., Huck J., Diffenderfer E., Dong L., Metz J., Koumenis C., Cengel K.A., Maity A., Busch T.M. (2021)
      In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy appear to produce fewer toxicities than standard dose rates while maintaining local tumor control. FLASHproton radiotherapy (F-PRT) ...

    • Mechanisms involved in the induced differentiation of leukemia cells 

      Tsiftsoglou, A. S.; Pappas, I. S.; Vizirianakis, I. S. (2003)
      Despite the remarkable progress achieved in the treatment of leukemias over the last several years, many problems (multidrug resistance [MDR], cellular heterogeneity, heterogeneous molecular abnormalities, karyotypic ...

    • Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy 

      Mueller A.L., O'Neill A., Jones T.I., Llach A., Rojas L.A., Sakellariou P., Stadler G., Wright W.E., Eyerman D., Jones P.L., Bloch R.J. (2019)
      Aberrant expression of DUX4, a gene unique to humans and primates, causes Facioscapulohumeral Muscular Dystrophy-1 (FSHD), yet the pathogenic mechanism is unknown. As transgenic overexpression models have largely failed ...

    • PKC and Ras differentially regulate gene expression of the dopaminergic marker TH and noradrenergic marker DBH 

      Theofilopoulos, S.; Tsirimonaki, E.; Sakellaridis, N.; Mangoura, D. (2007)
      We have successfully established for the first time in the literature cell lines from human fetal cells derived from the amniotic fluid (AF) and have documented that these cells may progress and stably express many of the ...

    • Positioning Europe for the EPITRANSCRIPTOMICS challenge 

      Jantsch M.F., Quattrone A., O'Connell M., Helm M., Frye M., Macias-Gonzales M., Ohman M., Ameres S., Willems L., Fuks F., Oulas A., Vanacova S., Nielsen H., Bousquet-Antonelli C., Motorin Y., Roignant J.-Y., Balatsos N., Dinnyes A., Baranov P., Kelly V., Lamm A., Rechavi G., Pelizzola M., Liepins J., Holodnuka Kholodnyuk I., Zammit V., Ayers D., Drablos F., Dahl J.A., Bujnicki J., Jeronimo C., Almeida R., Neagu M., Costache M., Bankovic J., Banovic B., Kyselovic J., Valor L.M., Selbert S., Pir P., Demircan T., Cowling V., Schäfer M., Rossmanith W., Lafontaine D., David A., Carre C., Lyko F., Schaffrath R., Schwartz S., Verdel A., Klungland A., Purta E., Timotijevic G., Cardona F., Davalos A., Ballana E., O'Carroll D., Ule J., Fray R. (2018)
      The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. ...

    • A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate 

      Giakountis A., Moulos P., Zarkou V., Oikonomou C., Harokopos V., Hatzigeorgiou A.G., Reczko M., Hatzis P. (2016)
      The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation, and proliferation in the intestinal epithelium. Constitutive, aberrant activity of the TCF4/β-catenin transcriptional complex is the ...

    • Stem cells’ centrosomes: How can organelles identified 130 years ago contribute to the future of regenerative medicine? 

      Goutas A., Trachana V. (2021)
      At the core of regenerative medicine lies the expectation of repair or replacement of damaged tissues or whole organs. Donor scarcity and transplant rejection are major obstacles, and exactly the obstacles that stem ...

    • Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities 

      Mentis A.-F.A., Dardiotis E., Grigoriadis N., Petinaki E., Hadjigeorgiou G.M. (2017)
      Viruses are directly or indirectly implicated in multiple sclerosis (MS). Here, we review the evidence on the virus-related pathophysiology of MS, introduce common experimental models, and explore the ways in which viruses ...