Όλο το DSpace

Πλοήγηση ανά Θέμα "ribonuclease"

Αποτελέσματα 1-9 από 9

    • The ammonium sulfate inhibition of human angiogenin 

      Chatzileontiadou D.S.M., Tsirkone V.G., Dossi K., Kassouni A.G., Liggri P.G.V., Kantsadi A.L., Stravodimos G.A., Balatsos N.A.A., Skamnaki V.T., Leonidas D.D. (2016)
      In this study, we investigate the inhibition of human angiogenin by ammonium sulfate. The inhibitory potency of ammonium sulfate for human angiogenin (IC50 = 123.5 ± 14.9 mm) is comparable to that previously reported for ...

    • Dual IRE1 RNase functions dictate glioblastoma development 

      Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

    • Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer 

      Boix E., Acquati F., Leonidas D., Pulido D. (2020)
      [No abstract available]

    • Functional Requirements for DjlA- and RraA-Mediated Enhancement of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR 

      Gialama D., Delivoria D.C., Michou M., Giannakopoulou A., Skretas G. (2017)
      In previous work, we have generated the engineered Escherichia coli strains SuptoxD and SuptoxR, which upon co-expression of the effector genes djlA or rraA, respectively, are capable of suppressing the cytotoxicity caused ...

    • Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC) 

      Balatsos, N. A. A.; Nilsson, P.; Mazza, C.; Cusack, S.; Virtanen, A. (2006)
      Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3′-exoribonuclease. Here we have investigated how the cap binding complex (CBC) affects human PARN activity. We showed that CBC, via its 80-kDa ...

    • Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance 

      Rubio-Patiño C., Bossowski J.P., De Donatis G.M., Mondragón L., Villa E., Aira L.E., Chiche J., Mhaidly R., Lebeaupin C., Marchetti S., Voutetakis K., Chatziioannou A., Castelli F.A., Lamourette P., Chu-Van E., Fenaille F., Avril T., Passeron T., Patterson J.B., Verhoeyen E., Bailly-Maitre B., Chevet E., Ricci J.-E. (2018)
      Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding ...

    • Mammary defences and immunity against mastitis in sheep 

      Katsafadou A.I., Politis A.P., Mavrogianni V.S., Barbagianni M.S., Vasileiou N.G.C., Fthenakis G.C., Fragkou I.A. (2019)
      The objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement systemand chemical antibacterial agents, to describe cooperation ...

    • Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: Prognostic value and impact on gene expression 

      Maragozidis P., Papanastasi E., Scutelnic D., Totomi A., Kokkori I., Zarogiannis S.G., Kerenidi T., Gourgoulianis K.I., Balatsos N.A.A. (2015)
      Background: Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and ...

    • Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1 

      Obiedat A., Seidel E., Mahameed M., Bernani O., Tsukerman P., Voutetakis K., Chatziioannou A., Mcmahon M., Avril T., Chevet E., Mandelboim O., Tirosh B. (2019)
      The unfolded protein response (UPR) is an adaptive signaling pathway activated in response to endoplasmic reticulum (ER) stress. The effectors of the UPR are potent transcription activators; however, some genes are suppressed ...