Πλοήγηση ανά Θέμα "proof of concept"
Αποτελέσματα 1-9 από 9
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Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation
(2019)Despite the clinical success of BRAF inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through "paradoxical MEK/ERK signaling" where transactivation of one protomer occurs as a result of ... -
An experimental workflow for studying barrier integrity, permeability, and tight junction composition and localization in a single endothelial cell monolayer: Proof of concept
(2021)Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The barrier paracellular permeability depends on the composition and spatial distribution of the cell-to-cell tight ... -
Media enhanced educational and training interventions for people at risk of Alzheimer's disease
(2017)Changes in cognition observed in Mild Cognitive Impairment (MCI) syndrome can be noticed by individuals and their families and in most cases this is the reason for asking for medical advice. Later on, computerized cognitive ... -
PET Counting Response Variability Depending on Tumor Location, Activity, and Patient Obesity: A Feasibility Study of Solitary Pulmonary Nodule Using Monte Carlo
(2019)We aim to investigate the counting response variations of positron emission tomography (PET) scanners with different detector configurations in the presence of solitary pulmonary nodule (SPN). Using experimentally validated ... -
A single load of fructose attenuates the risk of exercise-induced hypoglycemia in adults with type 1 diabetes on ultra-long-acting basal insulin: A randomized, open-label, crossover proof-of-principle study
(2020)OBJECTIVE While the adjustment of insulin is an established strategy to reduce the risk of exercise-associated hypoglycemia for individuals with type 1 diabetes, it is not easily feasible for those treated with ultra-long-acting ... -
Towards an open and decentralized case law curation ecosystem
(2020)Case law is the term that refers to reports of past court decisions. It is considered an essential source of law, vital for legal professionals. Existing case law services are currently centralized, with an entity having ... -
Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD
(2018)Long acting muscarinic antagonists (LAMA) are currently considered the therapeutic mainstay for patients with COPD and have been shown to improve clinical outcomes including symptoms, exercise capacity and airflow limitation. ... -
UniProt-Related Documents (UniReD): assisting wet lab biologists in their quest on finding novel counterparts in a protein network
(2020)The in-depth study of protein–protein interactions (PPIs) is of key importance for understanding how cells operate. Therefore, in the past few years, many experimental as well as computational approaches have been developed ... -
What Is the Required Certainty of Evidence for the Implementation of Novel Techniques for the Treatment of Benign Prostatic Obstruction?
(2019)Context: A large number of minimally invasive techniques have been developed for the surgical management of male lower urinary tract symptoms (LUTS) presumed to be secondary to benign prostatic obstruction (BPO) over the ...