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Parcourir par sujet "osteoclastogenesis"

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    • Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index 

      Rinotas V., Papakyriakou A., Violitzi F., Papaneophytou C., Ouzouni M.-D., Alexiou P., Strongilos A., Couladouros E., Kontopidis G., Eliopoulos E., Douni E. (2020)
      Receptor activator of nuclear factor-κB ligand (RANKL) constitutes the master mediator of osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has been approved for the treatment of postmenopausal ...

    • The infectious basis of ACPA-positive rheumatoid arthritis 

      Sakkas L.I., Daoussis D., Liossis S.-N., Bogdanos D.P. (2017)
      Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for ...

    • Porphyromonas gingivalis and rheumatoid arthritis 

      Perricone C., Ceccarelli F., Saccucci M., Di Carlo G., Bogdanos D.P., Lucchetti R., Pilloni A., Valesini G., Polimeni A., Conti F. (2019)
      Purpose of review: To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of Porphyromonas gingivalis. Recent findings: In the last decades our knowledge about the ...