• Alterations in xenobiotic-metabolizing enzyme activities across menstrual cycle in healthy volunteers 

      Asprodini E., Tsiokou V., Begas E., Kilindris T., Kouvaras E., Samara M., Messinis I. (2019)
      The purpose of the study was to determine whether the in vivo activities of drug-metabolizing enzymes CYP1A2 and CYP2A6, xanthine oxidase (XO), and N-acetyltransferase-2 (NAT2) vary across the menstrual cycle. Forty-two ...
    • The endocrine effects of multiple folliculogenesis 

      Messinis, I. E. (2011)
      Induction of multiple follicular development is a common practice in IVF programmes. Nevertheless, such an approach is not without implications. Apart from the high multiple pregnancy rate, marked changes in the secretion ...
    • Luteal-phase endocrinology 

      Messinis, I. E.; Messini, C. I.; Dafopoulos, K. (2009)
      The corpus luteum is formed from the pre-ovulatory follicle under the action of the mid-cycle LH surge. LH is the main luteotrophic hormone in women controlling luteal structure and function during the normal menstrual ...
    • Normal menstrual cycle steroid hormones variation does not affect the blood levels of total adiponectin and its multimer forms 

      Chatzidimitriou, K.; Gougoura, S. G.; Bargiota, A.; Koukoulis, G. N. (2015)
      Objective Plasma total adiponectin reveals a sexual dimorphism indicating that gonadal steroids may be involved in its secretion and/or metabolism. However, results from previous reports are conflicting and data regarding ...
    • Standards of Care in infertility in Europe 

      Messini C.I., Daponte A., Anifandis G., Mahmood T., Messinis I.E. (2016)
      Evidence-based medicine is the principal approach to medical practice. There are several debatable issues in infertility, which require clarification. Over the past 20 years, reliable methodology has been developed for the ...
    • Transdermal testosterone pretreatment in poor responders undergoing ICSI: A randomized clinical trial 

      Bosdou J.K., Venetis C.A., Dafopoulos K., Zepiridis L., Chatzimeletiou K., Anifandis G., Mitsoli A., Makedos A., Messinis I.E., Tarlatzis B.C., Kolibianakis E.M. (2016)
      STUDY QUESTION: Does pretreatment with transdermal testosterone increase the number of cumulus-oocyte complexes (COCs) retrieved by more than 1.5 in poor responders undergoing intracytoplasmic sperm injection (ICSI), using ...