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    • Characterizing miRNA–lncRNA Interplay 

      Karagkouni D., Karavangeli A., Paraskevopoulou M.D., Hatzigeorgiou A.G. (2021)
      Long noncoding RNAs (lncRNAs) are noncoding transcripts, usually longer than 200 nt, that constitute one of the largest and significantly heterogeneous RNA families. The annotation of lncRNAs and the characterization of ...

    • Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals 

      Papoutsopoulou S., Pollock L., Walker C., Tench W., Samad S.S., Bergey F., Lenzi L., Sheibani-Tezerji R., Rosenstiel P., Alam M.T., Martins Dos Santos V.A.P., Müller W., Campbell B.J. (2021)
      Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system has been extensively studied, ...

    • Novel HIF-2α interaction with Reptin52 impairs HIF-2 transcriptional activity and EPO secretion 

      Gkotinakou I.M., Befani C., Samiotaki M., Panayotou G., Liakos P. (2021)
      Hypoxia-inducible factor 2 (HIF-2), is essential for cellular response to hypoxia and holds an important role in erythropoiesis, angiogenesis, tissue invasion and metastasis, thus, constituting an important therapeutic ...

    • Potential dissociative glucocorticoid receptor activity for protopanaxadiol and protopanaxatriol 

      Karra A.G., Konstantinou M., Tzortziou M., Tsialtas I., Kalousi F.D., Garagounis C., Hayes J.M., Psarra A.-M.G. (2019)
      �Glucocorticoids are steroid hormones that regulate inflammation, growth, metabolism, and apoptosis via their cognate receptor, the glucocorticoid receptor (GR). GR, acting mainly as a transcription factor, activates or ...

    • The role of tissue oxygen tension in dengue virus replication 

      Frakolaki E., Kaimou P., Moraiti M., Kalliampakou K.I., Karampetsou K., Dotsika E., Liakos P., Vassilacopoulou D., Mavromara P., Bartenschlager R., Vassilaki N. (2018)
      Low oxygen tension exerts a profound effect on the replication of several DNA and RNA viruses. In vitro propagation of Dengue virus (DENV) has been conventionally studied under atmospheric oxygen levels despite that in ...