Πλοήγηση ανά Θέμα "dichloroacetic acid"
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Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the krebs cycle inhibitor LW6 on cellular and humoral alloimmunity
(2017)Cell metabolism is altered during T-cell and B-cell activation and differentiation. Clarifying the exact metabolic shifts may lead to the development of new immunosuppressive medications. In this study, the effect of the ... -
Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes
(2013)Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ... -
In human alloreactive CD4+ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets
(2016)Although kidney transplantation is the best therapy for end-stage renal disease, rejection remains a concern, and currently available immunosuppressive agents contribute to morbidity and mortality. Thus, novel immunosuppressive ... -
Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells
(2010)Aromatase, the enzyme that coverts testosterone to 17β-estradiol, has attracted attention lately because of its involvement in some forms of breast cancer in women. Studies are now undergoing on a variety of species to ...