Browsing by Subject "T98G"
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Bortezomib Downregulates MGMT Expression in T98G Glioblastoma Cells
(2013)The efficacy of treatment for glioblastoma multiforme is currently limited by the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine methyltransferase ... -
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NF kappa B and mutant p53
(2013)The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is a major determinant of glioma resistance to alkylating agents. Several strategies have been used to induce sensitization to alkylator-based treatments, ...