Browsing by Subject "National Academy of Sciences"
Now showing items 1-5 of 5
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Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures
(2021)The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic ... -
Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin
(2022)Human α2-macroglobulin (hα2M) is a multidomain protein with a plethora of essential functions, including transport of signaling molecules and endopeptidase inhibition in innate immunity. Here, we dissected the molecular ... -
Detecting different topologies immanent in scale-free networks with the same degree distribution
(2019)The scale-free (SF) property is a major concept in complex networks, and it is based on the definition that an SF network has a degree distribution that follows a power-law (PL) pattern. This paper highlights that not all ... -
Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system
(2021)Porphyromonas gingivalis is a keystone pathogen of the human dysbiotic oral microbiome that causes severe periodontitis. It employs a type-IX secretion system (T9SS) to shuttle proteins across the outer membrane (OM) for ... -
Reply to Harwood et al.: Alternative functional conformations of native human α2-macroglobulin
(2022)[No abstract available]