Πλοήγηση ανά Θέμα "L-NAME"

The 5-HT1A receptor and recognition memory possible modulation of its behavioral effects by the nitrergic system

Pitsikas, N.; Tsitsirigou, S.; Zisopoulou, S.; Sakellaridis, N. (2005)

Functional activation of the 5-HT1A receptor inhibits cognition, although discrepant findings have also been reported. The present study was designed to investigate the role of the 5-HT1A receptor on recognition memory in ...

Anesthetic Ketamine Impairs Rats' Recall of Previous Information The Nitric Oxide Synthase Inhibitor N-nitro-L-arginine Methylester Antagonizes This Ketamine-induced Recognition Memory Deficit

Boultadakis, A.; Pitsikas, N. (2011)

Background: There is poor experimental evidence concerning the effects of anesthetic doses of the noncompetitive N-methyl-D-aspartate receptor antagonist ketamine on rodents' memory abilities. The current study was designed ...

Effects of scopolamine and L-NAME on rats' performance in the object location test

Pitsikas, N. (2007)

The object location task is a new procedure evaluating spatial memory abilities in the rat. The aim of the present study was to characterize this behavioural paradigm by pharmacologic means. For this purpose, the effects ...

Effects of the nitric oxide synthase inhibitor L-NAME on different memory components as assessed in the object recognition task in the rat

Boultadakis, A.; Georgiadou, G.; Pitsikas, N. (2010)

Nitric oxide (NO) is sought to be an intracellular messenger in the central nervous system and its implication in learning and memory is well documented. Compounds that inhibit nitric oxide synthase (NOS), the key synthesizing ...

Effects of the Nitric Oxide Synthase Inhibitor L-NAME on Recognition and Spatial Memory Deficits Produced by Different NMDA Receptor Antagonists in the Rat

Boultadakis, A.; Pitsikas, N. (2010)

There is consistent experimental evidence that noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, such as ketamine, MK-801, and phencyclidine (PCP), impair cognition and produce psychotomimetic effects ...

The GABA(B) receptor and recognition memory: Possible modulation if its behavioral effects by the nitrergic system

Pitsikas, N.; Rigamonti, A. E.; Cella, S. G.; Muller, E. E. (2003)

Functional activation of the GABA(B) receptor inhibits learning and memory processes, though discrepant findings, in this context, have also been reported. The present study was designed to investigate the role of the ...

Memantine and recognition memory: Possible facilitation of its behavioral effects by the nitric oxide (NO) donor molsidomine

Pitsikas, N.; Sakellaridis, N. (2007)

The effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine on recognition memory were investigated in the rat by using the object recognition task. In addition, a possible interaction ...

Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat

Pitsikas, N.; Rigamonti, A. E.; Bonomo, S. M.; Cella, S. G.; Muller, E. E. (2003)

The present study was designed to investigate the role of nitric oxide (NO) on the acquisition of a recognition memory, task in the rat. For this purpose, the effects on memory exerted by pre-training administration of the ...

The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat

Pitsikas, N. (2009)

Nitric oxide (NO) is considered as an intracellular messenger in the brain. Its involvement in learning and memory processes has been proposed. Compounds that inhibit NO synthase (NOS), the key synthesizing enzyme, may ...