Πλοήγηση ανά Θέμα "INDUCED APOPTOSIS"
Αποτελέσματα 1-9 από 9
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Azithromycin has an antiproliferative and autophagic effect on airway smooth muscle cells
(2009)Azithromycin is used in long-term, low-dose treatment of airway diseases where airway wall remodelling is present. Since it improves total score symptom and respiratory function of such patients, we hypothesise that ... -
Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse
(2001)This study evaluated the frequency and the prognostic significance of bax, bcl-2 and p53 proteins in stage B and C adenocarcinomas of the colon and rectum. Paraffin-embedded specimens from 268 patients with colorectal ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
(2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts
(2006)Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization ... -
Expression patterns of endothelin-1 and its receptors in colorectal cancer
(2012)Background and Objectives Endothelin-1 (ET-1), a potent vasoconstricting peptide, plays an important role in carcinogenesis. Previous in vitro studies have shown that colorectal cancer cells produce ET-1. Methods: ET-1 and ... -
'Invading edge vs. inner' (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer
(2000)Neo-angiogenesis during neoplastic growth involves endothelial mitogenic and migration stimuli produced by cancer or tumour stromal cells. Although this active angiogenesis takes place in the tumour periphery, the process ... -
Oxidative stress due to radiation in CD34(+) Hematopoietic progenitor cells: protection by IGF-1
(2012)Radiation exerts direct as well as indirect effects on DNA through the generation of reactive oxygen species (ROS). Irradiated hematopoietic progenitor cells (HPCs) experience DNA strand breaks, favoring genetic instability, ... -
p53 and Cyclooxygenase-2 Expression are Directly Associated with Cyclin D1 Expression in Radical Prostatectomy Specimens of Patients with Hormone-Naive Prostate Cancer
(2012)Prostate cancer (PCa) is a potentially curable disease when diagnosed in early stages and subsequently treated with radical prostatectomy (RP). However, a significant proportion of patients tend to relapse early, with the ... -
Retinoid receptor alpha and beta expression in serous ovarian tumors
(2007)The expression of retinoid acid receptors alpha (RAR alpha) and beta (RAR beta) and estrogen receptor alpha (ER alpha) was assessed by immunohistochemistry and Western blotting in normal ovaries, serous cystadenoma (n = ...