Πλοήγηση ανά Θέμα "Hep-G2 cell line"

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Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode

Drakou C.E., Gardeli C., Tsialtas I., Alexopoulos S., Mallouchos A., Koulas S.M., Tsagkarakou A.S., Asimakopoulos D., Leonidas D.D., Psarra A.-M.G., Skamnaki V.T. (2020)

Anthocyanins (ACNs) are dietary phytochemicals with an acknowledged therapeutic significance. Pomegranate juice (PJ) is a rich source of ACNs with potential applications in nutraceutical development. Glycogen phosphorylase ...
Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase

Stravodimos G.A., Kantsadi A.L., Apostolou A., Kyriakis E., Kafaski-Kanelli V.-N., Solovou T., Gatzona P., Liggri P.G.V., Theofanous S., Gorgogietas V.A., Kissa A., Psachoula C., Lemonakis A., Chatzileontiadou D.S.M., Psarra A.-M.G., Skamnaki V.T., Haroutounian S.A., Leonidas D.E. (2018)

Background: Glycogen phosphorylase (GP) is a pharmaceutical target for the discovery of new antihyperglycaemic agents. Punica granatum is a well-known plant for its potent antioxidant and antimicrobial activities but so ...
Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures

Kouka P., Chatzieffraimidi G.-A., Raftis G., Stagos D., Angelis A., Stathopoulos P., Xynos N., Skaltsounis A.-L., Tsatsakis A.M., Kouretas D. (2018)

Background: Numerous studies have been carried out concerning the advantageous health effects, especially the antioxidant effects, of olive oil's (OO) individual biophenolic compounds, but none until now for its total ...
The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-D-glucopyranosyl thiazoles, imidazoles and an N-β-D glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design

Kyriakis E., Karra A.G., Papaioannou O., Solovou T., Skamnaki V.T., Liggri P.G.V., Zographos S.E., Szennyes E., Bokor É., Kun S., Psarra A.-M.G., Somsák L., Leonidas D.D. (2020)

C-Glucopyranosyl imidazoles, thiazoles, and an N-glucopyranosyl tetrazole were assessed in vitro and ex vivo for their inhibitory efficiency against isoforms of glycogen phosphorylase (GP; a validated pharmacological target ...
Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions

Karra A.G., Tziortziou M., Kylindri P., Georgatza D., Gorgogietas V.A., Makiou A., Krokida A., Tsialtas I., Kalousi F.D., Papadopoulos G.E., Papadopoulou K.Κ., Psarra A.-M.G. (2020)

Glucocorticoid (GCs) hormones exert their actions via their cognate steroid receptors the Glucocorticoid Receptors (GR), by genomic or non-genomic mechanisms of actions. GCs regulate many cellular functions among them ...
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Szabó K.E., Kyriakis E., Psarra A.-M.G., Karra A.G., Sipos Á., Docsa T., Stravodimos G.A., Katsidou E., Skamnaki V.T., Liggri P.G.V., Zographos S.E., Mándi A., Király S.B., Kurtán T., Leonidas D.D., Somsák L. (2019)

Epimeric series of aryl-substituted glucopyranosylidene-spiro-imidazolinones, an unprecedented new ring system, were synthesized from the corresponding Schiff bases of O-perbenzoylated (gluculopyranosylamine)onamides by ...
Glucosinolate biosynthesis in Eruca sativa

Katsarou D., Omirou M., Liadaki K., Tsikou D., Delis C., Garagounis C., Krokida A., Zambounis A., Papadopoulou K.K. (2016)

Glucosinolates (GSLs) are a highly important group of secondary metabolites in the Caparalles order, both due to their significance in plant-biome interactions and to their chemoprotective properties. This study identified ...
Granulin a synergizes with cisplatin to inhibit the growth of human hepatocellular carcinoma

Qiao G., Xu H., Li C., Li X., Farooqi A.A., Zhao Y., Liu X., Liu M., Stagos D., Lin X. (2018)

Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, due to resistance and toxicity, the application of cisplatin for the treatment of hepatocellular carcinoma (HCC) is limited. ...
HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

Karagiota A., Kourti M., Simos G., Mylonis I. (2019)

Hypoxia is frequently encountered in the microenvironment of solid tumors. Hypoxia-inducible factors (HIFs), the main effectors of cell response to hypoxia, promote cancer cell survival and progression. HIF-1α, the ...
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia

Pangou E., Befani C., Mylonis I., Samiotaki M., Panayotou G., Simos G., Liakos P. (2016)

Hypoxia inducible factor 2 (HIF-2) is a transcriptional activator implicated in the cellular response to hypoxia. Regulation of its inducible subunit, HIF-2α (also known as EPAS1), involves posttranslational modifications. ...
Manatee: detection and quantification of small non-coding RNAs from next-generation sequencing data

Handzlik J.E., Tastsoglou S., Vlachos I.S., Hatzigeorgiou A.G. (2020)

Small non-coding RNAs (sncRNAs) play important roles in health and disease. Next Generation Sequencing (NGS) technologies are considered as the most powerful and versatile methodologies to explore small RNA (sRNA) ...
A novel combined bioactivity / chemoactivity holistic approach for the evaluation of dietary supplements

Skaperda Z., Tekos F., Makri S., Angelakis C., Vassi E., Vardakas P., Patouna A., Terizi K., Kyriazi D., Kouretas D. (2021)

There is increasing evidence that the excessive generation of free radicals in the human body plays a major role in the pathophysiology and development of various diseases, closely associated with oxidative damage. In this ...
Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners

Karra A.G., Sioutopoulou A., Gorgogietas V., Samiotaki M., Panayotou G., Psarra A.-M.G. (2022)

Glucocorticoids are steroid hormones that regulate plethora biological actions such as growth and metabolism, immune response, and apoptosis. Glucocorticoids actions are mediated via glucocorticoid receptors which act ...
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Chetter B.A., Kyriakis E., Barr D., Karra A.G., Katsidou E., Koulas S.M., Skamnaki V.T., Snape T.J., Psarra A.-M.G., Leonidas D.D., Hayes J.M. (2020)

Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites ...
Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines

Kouka P., Tekos F., Valta K., Mavros P., Veskoukis A.S., Angelis A., Skaltsounis A.-L., Kouretas D. (2019)

Olive oil has held a prominent place in the Mediterranean diet since ancient times due to its beneficial effects on human health thus, becoming the subject of great scientific interest. Although numerous studies have ...

Πλοήγηση ανά Θέμα "Hep-G2 cell line"

Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode ﻿

Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase ﻿

Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures ﻿

The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-D-glucopyranosyl thiazoles, imidazoles and an N-β-D glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design ﻿

Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions ﻿

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography ﻿

Glucosinolate biosynthesis in Eruca sativa ﻿

Granulin a synergizes with cisplatin to inhibit the growth of human hepatocellular carcinoma ﻿

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia ﻿

HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia ﻿

Manatee: detection and quantification of small non-coding RNAs from next-generation sequencing data ﻿

A novel combined bioactivity / chemoactivity holistic approach for the evaluation of dietary supplements ﻿

Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners ﻿

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors ﻿

Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines ﻿

Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode

Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase

Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures

The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-D-glucopyranosyl thiazoles, imidazoles and an N-β-D glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design

Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Glucosinolate biosynthesis in Eruca sativa

Granulin a synergizes with cisplatin to inhibit the growth of human hepatocellular carcinoma

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia

Manatee: detection and quantification of small non-coding RNAs from next-generation sequencing data

A novel combined bioactivity / chemoactivity holistic approach for the evaluation of dietary supplements

Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines