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Πλοήγηση ανά Θέμα "HLA DRB1 antigen"

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    • Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease 

      Sarri C.A., Papadopoulos G.E., Papa A., Tsakris A., Pervanidou D., Baka A., Politis C., Billinis C., Hadjichristodoulou C., Mamuris Z. (2018)
      The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which ...

    • Associations of ABO, D, and Lewis blood groups and HLA Class I and Class II alleles with West Nile virus Lineage 2 disease outcome in Greece, 2010 to 2013 

      Politis C., Parara M., Kremastinou J., Hasapopoulou E., Iniotaki A., Siorenta A., Richardson C., Papa A., Kavallierou L., Asariotou M., Katsarou O., Mougiou A., Dadiotis L., Alexandropoulou Z., Megalou A., Magoula E., Papadopoulou M., Pervanidou D., Baka A., Hadjichristodoulou C. (2016)
      BACKGROUND: West Nile virus (WNV) infection, commonly asymptomatic, may cause mild West Nile fever (WNF) or potentially fatal neuroinvasive disease (WNND). An outbreak of 262 cases of the new Lineage 2 strain in Greece in ...

    • Deciphering the role of DNA methylation in multiple sclerosis: emerging issues 

      Sokratous M., Dardiotis E., Tsouris Z., Bellou E., Michalopoulou A., Siokas V., Arseniou S., Stamati T., Tsivgoulis G., Bogdanos D., Hadjigeorgiou G.M. (2016)
      Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence ...

    • Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach 

      Charitou T., Kontou P.I., Tamposis I.A., Pavlopoulos G.A., Braliou G.G., Bagos P.G. (2022)
      Available drugs have been used as an urgent attempt through clinical trials to minimize severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are limited data on common pharmacogenomics ...

    • Genetic contribution of MHC class II genes in susceptibility to west nile virus infection 

      Sarri C.A., Markantoni M., Stamatis C., Papa A., Tsakris A., Pervanidou D., Baka A., Politis C., Billinis C., Hadjichristodoulou C., Mamuris Z. (2016)
      WNV is a zoonotic neurotropic flavivirus that has recently emerged globally as a significant cause of viral encephalitis. The last five years, 624 incidents of WNV infection have been reported in Greece. The risk for severe ...

    • Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review 

      Tziastoudi M., Cholevas C., Stefanidis I., Theoharides T.C. (2022)
      COVID-19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed ...

    • HLA class II peptide-binding-region analysis reveals funneling of polymorphism in action 

      Sarri C.A., Giannoulis T., Moutou K.A., Mamuris Z. (2021)
      Background: HLA-class II proteins hold important roles in key physiological processes. The purpose of this study was to compile all class II alleles reported in human population and investigate patterns in pocket variants ...

    • Identification of the novel HLA-DRB1*11:192 allele by sequence-based typing in Greece 

      Sarri C.A., Markantoni M., Hadjichristidoulou C., Mamuris Z. (2016)
      The new allele DRB1*11:192 exon 2 differs from the DRB1*11:01:01:01 by three substitutions. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

    • The infectious basis of ACPA-positive rheumatoid arthritis 

      Sakkas L.I., Daoussis D., Liossis S.-N., Bogdanos D.P. (2017)
      Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for ...

    • Microbiome in multiple sclerosis; where are we, what we know and do not know 

      Boziki M.K., Kesidou E., Theotokis P., Mentis A.-F.A., Karafoulidou E., Melnikov M., Sviridova A., Rogovski V., Boyko A., Grigoriadis N. (2020)
      An increase of multiple sclerosis (MS) incidence has been reported during the last decade, and this may be connected to environmental factors. This review article aims to encapsulate the current advances targeting the study ...

    • Primary biliary cirrhosis: Family stories 

      Smyk, D.; Cholongitas, E.; Kriese, S.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)
      Primary biliary cirrhosis (PBC) is a chronic immune-mediated cholestatic liver disease of unknown aetiology which affects mostly women in middle age. Familial PBC is when PBC affects more than one member of the same family, ...

    • Replication study of GWAS risk loci in Greek multiple sclerosis patients 

      Hadjigeorgiou G.M., Kountra P.-M., Koutsis G., Tsimourtou V., Siokas V., Dardioti M., Rikos D., Marogianni C., Aloizou A.-M., Karadima G., Ralli S., Grigoriadis N., Bogdanos D., Panas M., Dardiotis E. (2019)
      Objectives: To validate in an ethnically homogeneous Greek multiple sclerosis (MS) cohort, genetic risk factors for the disease, identified through a number of previous multi-ethnic genome-wide association studies (GWAS). ...

    • Risk factor genes in patients with dystonia: A comprehensive review 

      Siokas V., Aloizou A.-M., Tsouris Z., Michalopoulou A., Mentis A.-F.A., Dardiotis E. (2019)
      Background: Dystonia is a movement disorder with high heterogeneity regarding phenotypic appearance and etiology that occurs in both sporadic and familial forms. The etiology of the disease remains unknown. However, there ...

    • Smoke and autoimmunity: The fire behind the disease 

      Perricone C., Versini M., Ben-Ami D., Gertel S., Watad A., Segel M.J., Ceccarelli F., Conti F., Cantarini L., Bogdanos D.P., Antonelli A., Amital H., Valesini G., Shoenfeld Y. (2016)
      The association between smoke habit and autoimmunity has been hypothesized a long time ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it may trigger the development of autoantibodies ...