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Πλοήγηση ανά Θέμα "CD19 antigen"

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    • Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis 

      Zachou K., Arvaniti P., Lyberopoulou A., Sevdali E., Speletas M., Ioannou M., Koukoulis G.K., Renaudineau Y., Dalekos G.N. (2022)
      Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ...

    • BAFF receptor polymorphisms and deficiency in humans 

      Sevdali E., Block Saldana V., Speletas M., Eibel H. (2021)
      The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including ...

    • Breg Cells Are Numerically Decreased and Functionally Impaired in Patients with Systemic Sclerosis 

      Mavropoulos A., Simopoulou T., Varna A., Liaskos C., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2016)
      Objective Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number ...

    • IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells 

      Mavropoulos A., Varna A., Zafiriou E., Liaskos C., Alexiou I., Roussaki-Schulze A., Vlychou M., Katsiari C., Bogdanos D.P., Sakkas L.I. (2017)
      Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10 + Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and ...

    • The role of B cells in the pathogenesis of systemic sclerosis 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by extensive collagen deposition, microvasculopathy and autoantibodies. All three features can be promoted by activation of T cells and B cells. T cells are of Th2 type producing ...

    • Systemic sclerosis: New evidence re-enforces the role of B cells 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ...

    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis 

      Madireddy L., Patsopoulos N.A., Cotsapas C., Bos S.D., Beecham A., McCauley J., Kim K., Jia X., Santaniello A., Caillier S.J., Andlauer T.F.M., Barcellos L.F., Berge T., Bernardinelli L., Martinelli-Boneschi F., Booth D.R., Briggs F., Celius E.G., Comabella M., Comi G., Cree B.A.C., D’Alfonso S., Dedham K., Duquette P., Efthimios D., Esposito F., Fontaine B., Gasperi C., Goris A., Dubois B., Gourraud P.-A., Hadjigeorgiou G., Haines J., Hawkins C., Hemmer B., Hintzen R., Horakova D., Isobe N., Kalra S., Kira J.-I., Khalil M., Kockum I., Lill C.M., Lincoln M.R., Luessi F., Martin R., Oturai A., Palotie A., Pericak-Vance M.A., Henry R., Saarela J., Ivinson A., Olsson T., Taylor B.V., Stewart G.J., Harbo H.F., Compston A., Hauser S.L., Hafler D.A., Zipp F., De Jager P., Sawcer S., Oksenberg J.R., Baranzini S.E., International Multiple Sclerosis Genetics Consortium (2019)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...