Listar por tema "Breast Neoplasms"

Accelerated hypofractionated radiotherapy schedules in breast cancer: A review of the current literature

Kalogeridi, M. A.; Kelekis, N.; Kouvaris, J.; Platoni, K.; Kyrias, G.; Pectasides, D.; Kouloulias, V. (2009)

Lumpectomy followed by breast irradiation is an alternative to mastectomy for patients with early-stage breast cancer. The purpose of radiation treatment following lumpectomy is to minimize the risk of recurrent cancer in ...

Adherence to Mediterranean Diet and Nutritional Status in Women with Breast Cancer: What Is Their Impact on Disease Progression and Recurrence-Free Patients’ Survival?

Mantzorou M., Tolia M., Poultsidi A., Vasios G.K., Papandreou D., Theocharis S., Kavantzas N., Troumbis A.Y., Giaginis C. (2022)

Introduction: Nutritional status impacts the survival of patients with cancer. There are few studies that investigate the role of nutritional status on breast cancer survival in women with breast cancer, and even fewer ...

Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

Sahpazidou, D.; Geromichalos, G. D.; Stagos, D.; Apostolou, A.; Haroutounian, S. A.; Tsatsakis, A. M.; Tzanakakis, G. N.; Hayes, A. W.; Kouretas, D. (2014)

A major part of the wineries' wastes is composed of grape stems which are discarded mainly in open fields and cause environmental problems due mainly to their high polyphenolic content. The grape stem extracts' use as a ...

Application of Radiomics and Decision Support Systems for Breast MR Differential Diagnosis

Tsougos I., Vamvakas A., Kappas C., Fezoulidis I., Vassiou K. (2018)

Over the years, MR systems have evolved from imaging modalities to advanced computational systems producing a variety of numerical parameters that can be used for the noninvasive preoperative assessment of breast pathology. ...

BRCA1 and BRCA2 germline testing in Cretan isolates reveals novel and strong founder effects

Apostolou P., Fostira F., Kouroussis C., Kalfakakou D., Delimitsou A., Agelaki S., Androulakis N., Christodoulou C., Kalbakis K., Kalykaki A., Sanidas E., Papadimitriou C., Vamvakas L., Georgoulias V., Mavroudis D., Yannoukakos D., Konstantopoulou I., Saloustros E. (2020)

Germline BRCA1 and BRCA2 loss-of-function variants have been linked to increased breast and ovarian cancer risk, with more than 5,000 distinct pathogenic variants being reported worldwide. Among individuals of Greek descent, ...

Breast Cancer Classification on Multiparametric MRI – Increased Performance of Boosting Ensemble Methods

Vamvakas A., Tsivaka D., Logothetis A., Vassiou K., Tsougos I. (2022)

Introduction: This study aims to assess the utility of Boosting ensemble classification methods for increasing the diagnostic performance of multiparametric Magnetic Resonance Imaging (mpMRI) radiomic models, in differentiating ...

Breast cancer status in Greece: 35-Years experience [1]

Tsakraklides, V.; Apostolikas, N.; Gourgoulianis, K.; Agnantis, N. (2002)

Breast radiotherapy and early adverse cardiac effects. The role of serum biomarkers and strain echocardiography

Gkantaifi A., Papadopoulos C., Spyropoulou D., Toumpourleka M., Iliadis G., Kardamakis D., Nikolaou M., Tsoukalas N., Kyrgias G., Tolia M. (2019)

Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the ...

Circulating tumor cells as prognostic biomarkers in breast cancer: current status and future prospects

Chantzara E., Xenidis N., Kallergi G., Georgoulias V., Kotsakis A. (2021)

Introduction : Despite advances in diagnostic and therapeutic techniques breast cancer is still associated with significant morbidity and mortality. CTCs play a crucial role in the metastatic process, which is the main ...

Clinical validation of the LKB model and parameter sets for predicting radiation-induced pneumonitis from breast cancer radiotherapy

Tsougos, I.; Mavroidis, P.; Theodorou, K.; Rajala, J.; Pitkänen, M. A.; Holli, K.; Ojala, A. T.; Hyödynmaa, S.; Järvenpää, R.; Lind, B. K.; Kappas, C. (2006)

The choice of the appropriate model and parameter set in determining the relation between the incidence of radiation pneumonitis and dose distribution in the lung is of great importance, especially in the case of breast ...

Computer-based automated estimation of breast vascularity and correlation with breast cancer in DCE-MRI images

Kostopoulos S.A., Vassiou K.G., Lavdas E.N., Cavouras D.A., Kalatzis I.K., Asvestas P.A., Arvanitis D.L., Fezoulidis I.V., Glotsos D.T. (2017)

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with gadolinium constitutes one of the most promising protocols for boosting up the sensitivity in breast cancer detection. The aim of this study was twofold: ...

Contrast-enhanced and unenhanced diffusion-weighted imaging of the breast at 3 T

Fanariotis M., Tsougos I., Vlychou M., Fezoulidis I., Vassiou K. (2018)

Aim: To evaluate the effect of intravenous gadolinium contrast agent on diffusion-weighted sequences and apparent diffusion coefficient (ADC) measurements at 3 T. Materials and methods: Sixty-two biopsy-proven breast lesions ...

Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform

Gkretsi V., Kalli M., Efstathiades C., Papageorgis P., Papanikolaou V., Zacharia L.C., Tsezou A., Athanassiou E., Stylianopoulos T. (2019)

Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin ...

Diagnostic performance of quantitative diffusion tensor imaging for the differentiation of breast lesions at 3 T MRI

Tsougos I., Bakosis M., Tsivaka D., Athanassiou E., Fezoulidis I., Arvanitis D., Vassiou K. (2019)

Background: Conventional breast magnetic resonance imaging (MRI), including dynamic contrast-enhanced MR mammography, may lead to ambiguous diagnosis and unnecessary biopsies. Purpose: To investigate the contribution of ...

Dynamic changes of CTCs in patients with metastatic HR(+)/HER2(−) breast cancer receiving salvage treatment with everolimus/exemestane

Spiliotaki M., Kallergi G., Nikolaou C., Xenidis N., Politaki E., Apostolaki S., Georgoulia N., Koinis F., Tsoukalas N., Hatzidaki D., Kotsakis A., Georgoulias V. (2021)

Purpose: Detection of CTCs represents a poor prognostic factor in patients with early and metastatic breast cancer (mBC) and treatment with everolimus–exemestane (E/E) is an established effective treatment in hormone ...

Effects of TP53 and PIK3CA mutations in early breast cancer: a matter of co-mutation and tumor-infiltrating lymphocytes

Kotoula V., Karavasilis V., Zagouri F., Kouvatseas G., Giannoulatou E., Gogas H., Lakis S., Pentheroudakis G., Bobos M., Papadopoulou K., Tsolaki E., Pectasides D., Lazaridis G., Koutras A., Aravantinos G., Christodoulou C., Papakostas P., Markopoulos C., Zografos G., Papandreou C., Fountzilas G. (2016)

The purpose of this study is to investigate whether the outcome of breast cancer (BC) patients treated with adjuvant chemotherapy is affected by co-mutated TP53 and PIK3CA according to stromal tumor-infiltrating lymphocytes ...

Endocrine resistance and epigenetic reprogramming in estrogen receptor positive breast cancer

Dimitrakopoulos F.-I., Kottorou A., Tzezou A. (2021)

Despite the enormous advances during the last three decades, breast cancer continues to be the most frequent type of cancer as well as one of the most frequent cancer-related causes of death in women. Therapeutic management ...

Epithelial-to-mesenchymal transition heterogeneity of circulating tumor cells and their correlation with mdscs and tregs in HER2-negative metastatic breast cancer patients

Papadaki M.A., Aggouraki D., Vetsika E.-K., Xenidis N., Kallergi G., Kotsakis A., Georgoulias V. (2021)

Background: To investigate the correlation between circulating tumor cells (CTCs) bearing cancer stem cell (CSC) and epithelial-to-mesenchymal (EMT) phenotypes and the different immunosuppressive cells in peripheral blood ...

Evaluation of the irradiated volume of the heart and cardiac substructures after left breast radiotherapy

Gkantaifi A., Papadopoulos C., Spyropoulou D., Toumpourleka M., Iliadis G., Tsoukalas N., Kyrgias G., Tolia M. (2020)

Backround/Aim: Adjuvant radiotherapy in patients with cancer of the left breast may lead to impaired cardiac function. The aim of our prospective study is to evaluate (i) doses to the irradiated volume of the heart and its ...

An exploratory study of radiation dermatitis in breast cancer patients

Alexopoulou E., Katsila T., Tolia M., Tsoukalas N., Leontsinidis M., Kyrgias G., Kouloulias V., Patrinos G.P., Spyropoulou D., Kardamakis D. (2018)

Background/Aim: Radiation dermatitis is observed in 95% of breast cancer patients receiving radiotherapy. The aim of this study was to explore the correlation between protein expression in tumor cells and the risk of ...